Home Immunology & Inflammation Immunology & Inflammation related modulator Quadrol

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Quadrol Immunology & Inflammation related modulator

Cat.No.E8325

Quadrol (N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine, EDTP) is an immunostimulant which is considered as a potentially useful active molecule for accelerating wound healing. Quadrol can form a complex with Ca²⁺, mediate the entry of Ca²⁺ into macrophages, and stimulate macrophage activation.
Quadrol Immunology & Inflammation related modulator Chemical Structure

Chemical Structure

Molecular Weight: 292.42

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Chemical Information, Storage & Stability

Molecular Weight 292.42 Formula

C14H32N2O4

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CAS No. 102-60-3 Download SDF Storage of Stock Solutions

Synonyms N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine; EDTP Smiles CC(O)CN(CC(O)C)CCN(CC(O)C)CC(O)C

Mechanism of Action

In vivo

On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5).
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