Pentoxifylline

For research use only.

Catalog No.S4345

1 publication

Pentoxifylline Chemical Structure

Molecular Weight(MW): 278.31

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.

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Selleck's Pentoxifylline has been cited by 1 publication

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Biological Activity

Description Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
In vitro

Pentoxifylline exhibits synergism with CDDP in killing MCF-7/E6 cells but does not affect sensitivity of the control cells. Pentoxifylline inhibits G2 checkpoint function to a greater extent in MCF-7/E6 than in the parental cells. [1] Pentoxifylline acts primarily by increasing red blood cell deformability, by reducing blood viscosity and by decreasing the potential for platelet aggregation and thrombus formation. [2] Pentoxifylline is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity. Pentoxifylline (10 μM) suppresses the production of both biologically active TNF and TNF mRNA expression by more than 50% in LM cells. [3] Pentoxifylline blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation in RAW 264.7 macrophages. Pentoxifylline combined with Dexamethasone causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone in RAW 264.7 macrophages. [4]

In vivo Pentoxifylline (500 mg) markedly inhibits increases in the serum levels of TNF and IL-6, as well as the effects on coagulation and fibrinolysis, in chimpanzees. Pentoxifylline (500 mg) along with Endotoxin (4 ng/kg) also has a significant effect on thrombin generation in chimpanzees. [5]

Protocol

Solubility (25°C)

In vitro DMSO 55 mg/mL (197.62 mM)
Water 55 mg/mL (197.62 mM)
Ethanol 55 mg/mL (197.62 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 278.31
Formula

C13H18N4O3

CAS No. 6493-05-6
Storage powder
in solvent
Synonyms N/A
Smiles C[N]1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID