CAS No. 306-07-0

Batch: Purity:99.99
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Pargyline hydrochloride Chemical Structure
Chemical Structure
Check the Pargyline hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-benzyl-N-methylprop-2-yn-1-amine;hydrochloride
CAS Number 306-07-0
Molecular Formula

C11H13N.HCl
Molecular Weight (MW) 195.69
SMILES CN(CC#C)CC1=CC=CC=C1.Cl
InChIKey BCXCABRDBBWWGY-UHFFFAOYSA-N

Ordering Information

Biological Activity

Pargyline hydrochloride is an irreversible inhibitor of monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), and lysine-specific demethylase 1 (LSD1). By targeting LSD1, pargyline blocks histone demethylation, leading to alterations in chromatin structure and repression of androgen receptor-dependent gene transcription. This pathway modulation suppresses gene expression and affects downstream cellular phenotypes related to chromatin organization. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 39 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 39 mg/mL
Ethanol 39 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.