CAS No. 42794-76-3
Batch:
Purity:98
Chemical Structure
Check the
Midodrine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 42794-76-3 | |
|---|---|---|
| Molecular Formula |
C12H18N2O4 |
|
| Molecular Weight (MW) | 254.28 | |
| SMILES | COC1=CC(=C(C=C1)OC)C(CNC(=O)CN)O |
Midodrine is a prodrug vasopressor that acts as a selective alpha-1 adrenergic receptor agonist through its active metabolite, desglymidodrine. Activation of alpha-1 adrenergic receptors triggers the Gq protein-coupled signaling pathway, leading to phospholipase C activation and intracellular calcium mobilization. This signaling cascade stimulates vascular smooth muscle contraction, inducing peripheral arteriolar and venous vasoconstriction that enhances systemic vascular resistance and elevates blood pressure.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
51 mg/mL
(200.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.