CAS No. 2275619-53-7
Batch:
Purity:99.06
Chemical Structure
Check the
MDL-800
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | methyl 2-[(5-bromo-4-fluoro-2-methylphenyl)sulfamoyl]-5-[(3,5-dichlorophenyl)sulfonylamino]benzoate | |
|---|---|---|
| CAS Number | 2275619-53-7 | |
| Molecular Formula |
C21H16BrCl2FN2O6S2 |
|
| Molecular Weight (MW) | 626.30 | |
| InChIKey | FKFQBYBODAKGOA-UHFFFAOYSA-N |
Biological Activity
MDL-800 is a selective allosteric activator of sirtuin 6 (SIRT6) deacetylation over other sirtuins and histone deacetylases. Pharmacological activation of SIRT6 by MDL-800 reduces histone H3 acetylation levels and induces cell cycle arrest. Consequently, this target activation suppresses cancer cell proliferation in hepatocellular carcinoma and non-small cell lung carcinoma models in vitro and in vivo. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(159.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.