CAS No. 1103500-20-4
Batch:
Purity:99.75
Chemical Structure
Check the
LY2562175
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1103500-20-4 | |
|---|---|---|
| Molecular Formula |
C28H27Cl2N3O4 |
|
| Molecular Weight (MW) | 540.44 | |
| SMILES | CN1C=C(C2=C1C=C(C=C2)N3CCC(CC3)OCC4=C(ON=C4C5=C(C=CC=C5Cl)Cl)C6CC6)C(=O)O |
Biological Activity
LY2562175 is a potent and selective agonist of the farnesoid X receptor (FXR). FXR is a nuclear receptor that plays a critical role in controlling bile acid, lipid, and glucose metabolism. By selectively activating FXR, LY2562175 drives the transcriptional activation of FXR-dependent gene networks, thereby regulating metabolic signaling pathways and maintaining cellular metabolic homeostasis. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(185.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1.5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.