LY310762 HCl

Catalog No.S2669

For research use only.

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.

LY310762 HCl Chemical Structure

CAS No. 192927-92-7

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Biological Activity

Description LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
5-HT1D [1]
249 nM(Ki)
In vitro

LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40%. [1] LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan. [2]

In vivo Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312±43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases basal levels of 5-HT above vehicle controls, reaching a maximum of 258% compared to the pre-injection control. [1]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 0.4 mg/mL
(0.92 mM)
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 430.94


CAS No. 192927-92-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1(C2=CC=CC=C2N(C1=O)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F)C.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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