Name: Liothyronine Sodium
Brand: Selleck Chemicals
SKU: S4217
Availability: InStock
Rating: 5 (2 reviews)

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Quality Control

Batch: Purity: 99.41%

99.41

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other THR Inhibitors	MGL-3196 (Resmetirom) L-Thyroxine sodium salt pentahydrate TI17 dextrothyroxine sodium Eprotirome (KB2115) Tiratricol ALG-055009

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (148.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.300mg/ml (0.45mM)	Taking the 1 mL working solution as an example, add 50 μL of 6 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	672.96	Formula	C₁₅H₁₂I₃NO₄.Na	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	55-06-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Cytomel			SMILES	C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+]

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	thyroid hormone receptorα thyroid hormone receptor β-1
In vitro	Liothyronine Sodium is the most potent form of thyroid hormone. Chemically, it is nearly identical to triiodothyronine (T₃). It targets thyroid hormone receptorα and thyroid hormone receptor β-1 . As such, it acts on the body to increase the basal metabolic rate, effect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness.
References	[1] https://pubmed.ncbi.nlm.nih.gov/14596673/ [2] https://pubmed.ncbi.nlm.nih.gov/17315033/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-24)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07346157	RECRUITING	Medulloblastoma; Medulloblastoma, Childhood; Medulloblastoma Recurrent	Sabine Mueller, MD, PhD	2026-08-21	PHASE1; PHASE2
NCT07568574	ENROLLING_BY_INVITATION	Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes	Enhanced Emirates Limited	2026-03-12
NCT05682482	RECRUITING	Autoimmune Hypothyroidism	M. Medici	2022-10-07	PHASE3
NCT06731764	RECRUITING	Hypothyroidism	UConn Health	2024-12-10	PHASE2; PHASE3
NCT07424183	NOT_YET_RECRUITING	Hypothyroidism Primary	University of Pennsylvania	2026-11	PHASE2
NCT04115514	ACTIVE_NOT_RECRUITING	ARDS, Human; Lung, Wet; Thyroid; Pulmonary Edema; Lung Inflammation	University of Minnesota	2020-03-30	PHASE2

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Liothyronine Sodium THR activator

Chemical Structure

Molecular Weight: 672.96