Hydroquinone

Catalog No.S4580 Synonyms: Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ

For research use only.

Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ) is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.

Hydroquinone Chemical Structure

CAS No. 123-31-9

Selleck's Hydroquinone has been cited by 2 Publications

Purity & Quality Control

Choose Selective ROS Inhibitors

Biological Activity

Description Hydroquinone (Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ) is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
In vitro

At 50 µM HQ(Hydroquinone), R-28 cells show a significant decrease in cell viability compared with the dimethyl sulfoxide (DMSO)-treated controls. At the 100–500 µM concentrations, all three cell lines show significant cell death (P <0.001). In the ARPE-19, R-28, and HMVEC cultures, the caspase-3/7 activities are not increased at any of the HQ concentration. Neuroretinal R-28 cells are more sensitive to HQ than the ARPE-19 and HMVEC cultures[1].

In vivo In vivo exposure of rats to HQ results in changes of immune response mirrored by impairing allergic lung response to ovalbumin, an antigen unrelated to HQ. HQ exposure impairs the expression of CD45R and CD6 co-stimulatory molecules on activated spleen lymphocytes and diminishes the levels of OA(ovalbumin)-anaphylactic antibodies and the subsequent mast cell degranulation in sensitized rats challenged with OA[2].

Protocol (from reference)

Cell Research:

[1]

  • Cell lines: ARPE-19, R-28, and HMVEC
  • Concentrations: 500 µM, 200 µM, 100 µM, 50 µM
  • Incubation Time: 24 h
  • Method:

    ARPE-19, R-28, and HMVEC are treated for 24 h with four different concentrations of HQ (500 µM, 200 µM, 100 µM, 50 µM). Cell viability, caspase-3/7 activation, DNA laddering patterns, and lactate dehydrogenase (LDH) levels are analyzed.

Animal Research:

[2]

  • Animal Models: Male Wistar rats
  • Dosages: 50 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

DMSO 22 mg/mL
(199.8 mM)
Water 22 mg/mL
(199.8 mM)
Ethanol '22 mg/mL

Chemical Information

Molecular Weight 110.11
Formula

C6H6O2

CAS No. 123-31-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=CC=C1O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05098509 Not yet recruiting Drug: RAD011|Drug: Placebo Prader-Willi Syndrome Radius Pharmaceuticals Inc. January 3 2022 Phase 2|Phase 3
NCT05018039 Not yet recruiting Other: Collaborarive Care Model Mental Disorder|Musculoskeletal Diseases Royal National Orthopaedic Hospital NHS Trust October 2021 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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