Catalog No.S4580 Synonyms: Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ
Molecular Weight(MW): 110.11
Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.
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|Description||Hydroquinone is a Melanin Synthesis Inhibitor. The physiologic effect of hydroquinone is by means of Depigmenting Activity. It also posesses antioxidant properties that can cause toxicity in several organs, notably the kidney.|
At 50 µM HQ(Hydroquinone), R-28 cells show a significant decrease in cell viability compared with the dimethyl sulfoxide (DMSO)-treated controls. At the 100–500 µM concentrations, all three cell lines show significant cell death (P <0.001). In the ARPE-19, R-28, and HMVEC cultures, the caspase-3/7 activities are not increased at any of the HQ concentration. Neuroretinal R-28 cells are more sensitive to HQ than the ARPE-19 and HMVEC cultures.
|In vivo||In vivo exposure of rats to HQ results in changes of immune response mirrored by impairing allergic lung response to ovalbumin, an antigen unrelated to HQ. HQ exposure impairs the expression of CD45R and CD6 co-stimulatory molecules on activated spleen lymphocytes and diminishes the levels of OA(ovalbumin)-anaphylactic antibodies and the subsequent mast cell degranulation in sensitized rats challenged with OA.|
|In vitro||DMSO||22 mg/mL (199.8 mM)|
|Water||22 mg/mL (199.8 mM)|
|Ethanol||22 mg/mL (199.8 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
|Synonyms||Quinol, 1,4-Benzenediol, 1,4-Dihydroxybenzene, HQ|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03456986||Not yet recruiting||Age Related Cognitive Decline||Perception Dynamics Institute|University of California San Diego|University of South Alabama||September 4 2018||Not Applicable|
|NCT03035565||Recruiting||Heart Failure NYHA Class II|Heart Failure NYHA Class III|Heart Failure NYHA Class I||Indiana University||February 22 2017||Not Applicable|
|NCT03638882||Recruiting||Executive Function||Rotman Research Institute at Baycrest|University of Toronto||September 2018||Not Applicable|
|NCT02929381||Recruiting||Polyps|Neoplasms||Miroslaw Szura|Specialist Diagnostic and Therapeutic Center MEDICINA|Jagiellonian University||June 2016||Not Applicable|
|NCT02506036||Unknown status||Frontotemporal Dementia|Right Sided Cerebral Hemisphere Cerebrovascular Accident||Johns Hopkins University|University of California San Francisco||August 2015||Not Applicable|
|NCT02340377||Terminated||Core Body Temperature||University of Arizona||January 2015||--|
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