Homosalate

Synonyms: HMS, Homomenthyl salicylate

Homosalate (HMS, Homomenthyl salicylate) is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.

Homosalate Chemical Structure

Homosalate Chemical Structure

CAS: 118-56-9

Purity & Quality Control

Batch: S457201 Purity: 99.19%
99.19

Homosalate Related Products

Signaling Pathway

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Biological Activity

Description Homosalate (HMS, Homomenthyl salicylate) is an organic ultraviolet filter used in most sunscreens but has been reported to be toxic to marine organisms. Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways.
In vitro
In vitro

Extracellular vesicles (EVs) released by Homosalate‐treated cells enhance resistance to anchorage loss in another recipient epithelial tumour cell line.[2]

Cell Research Cell lines MDA‐MB‐231 parental cells
Concentrations 10 μM
Incubation Time 24 h
Method

For EV isolation, 6 × 106 of MDA‐MB‐231 parental cells were seeded per 15 cm culture dish in an optimized number of dishes to obtain 70 × 106, 27 × 106 or 50 × 106 secreting cells. After 24 h, cells were washed 1 X with PBS and 15 ml of serum free, phenol red free Leibovitz's L‐15 were added. DMSO (0.1%), Homosalate (10 μM) or Bafilomycin A1 (100 nM) were added to phenol‐red free, serum‐free Leibovitz's L‐15 medium incubated on cells during 24 h (DMSO and Homosalate) or 16 h (Bafilomycin A1). The day after, cells were counted and the percentage of cell viability was determined using Trypan Blue.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04950543 Completed
Quality of Life
Charite University Berlin Germany
July 5 2021 --
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October 10 2019 Not Applicable
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April 23 2019 Phase 1
NCT04426708 Completed
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February 18 2019 Phase 1
NCT03158506 Completed
Healthy Subject
Hua Medicine Limited
March 29 2017 Phase 1

Chemical Information & Solubility

Molecular Weight 262.34 Formula

C16H22O3

CAS No. 118-56-9 SDF --
Density 1.045 g/mL
Smiles CC1CC(CC(C)(C)C1)OC(=O)C2=C(O)C=CC=C2
Storage (From the date of receipt) 2 years -20°C liquid

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