Granisetron

Catalog No.S5052 Synonyms: Sancuso, Kevatril, Granisetronum, Sustol

For research use only.

Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.

Granisetron Chemical Structure

CAS No. 109889-09-0

Purity & Quality Control

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Biological Activity

Description Granisetron (Sancuso, Kevatril, Granisetronum, Sustol) is a serotonin receptor (5HT-3 selective) antagonist that is used as an antiemetic and antinauseant for cancer chemotherapy.
Targets
5HT-3 [1]
()
In vitro

In radioligand binding studies on rat brain membranes, BRL 43694 had little or no affinity for 5-HT1A, 5-HT1B , 5-HT2 or for many other binding sites[1].

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 11 mg/mL
(35.21 mM)
Ethanol '-1 mg/mL

Chemical Information

Molecular Weight 312.41
Formula

C18H24N4O

CAS No. 109889-09-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1C2CCCC1CC(C2)NC(=O)C3=NN(C4=CC=CC=C43)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04918862 Completed Drug: Granisetron 1mg Vs 3 mg of Granisetron Cairo University|Mohamed Yousry Mohamed|Tamer Fayez Safan|Tamer Mohamed Khair|Mohamed Ahmed A. M.D.|Islam Mohamed Sayed January 8 2021 Phase 3
NCT01416259 Completed Drug: Withdraw treatment Healthy Heron Therapeutics July 2011 --

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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