CAS No. 150417-90-6
Batch:
Purity:100.00
Chemical Structure
Check the
GC7 Sulfate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-(7-aminoheptyl)guanidine;sulfuric acid | |
|---|---|---|
| CAS Number | 150417-90-6 | |
| Molecular Formula |
C8H22N4O4S |
|
| Molecular Weight (MW) | 270.35 | |
| SMILES | NCCCCCCCNC(N)=N.O[S](O)(=O)=O | |
| InChIKey | MDDOWYFCKAAANU-UHFFFAOYSA-N |
Biological Activity
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHPS). By suppressing DHPS activity, GC7 blocks eukaryotic translation initiation factor 5A activation to impair cell proliferation. In neuroblastoma cells, GC7 inhibits proliferation in a dose-dependent manner through the induction of the cell cycle inhibitor p21 and a reduction of total and phosphorylated retinoblastoma protein levels, ultimately driving cell cycle arrest. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 5 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 3 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.