Furazolidone

For research use only.

Catalog No.S4528

1 publication

Furazolidone Chemical Structure

CAS No. 67-45-8

Furazolidone is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.

Selleck's Furazolidone has been cited by 1 publication

Purity & Quality Control

Choose Selective Bacterial Inhibitors

Biological Activity

Description Furazolidone is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.
In vitro

Furazolidone displays potent antiproliferative properties at submicromolar concentrations and induces apoptosis in AML cell lines. Furazolidone treatment of certain AML cells induces myeloid cell differentiation by morphology and flow cytometry for CD11b expression, resulting in increased stability of tumor suppressor p53 protein in AML cells[1].

In vivo FZ accelerates its own metabolism in the chicken by induction of the activity of CPR whereas no effect is observed in the rat[2].

Protocol

Cell Research:

[1]

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  • Cell lines: The leukemic cells(Kasumi-1, NB4 and MolM-13)
  • Concentrations: from 1 µM to 50 µM
  • Incubation Time: 24, 48 and 72 hours
  • Method:

    Leukemic cells are seeded in 96-well culture plates at a density of 1 or 2×104 viable cells/100 µl/well in triplicates and are treated for 24, 48, and 72 hours with an incremental concentration of FZD ranging from 1 µM to 50 µM. Colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation assay is used to determine the cytotoxicity. The optical density at 492 nm is measured using a Multiskan Ascent® microplate photometer. IC50 values are determined by MTS assay when cells are treated with FZD for 72 hours and calculated with GraphPad Prism 5. Each experiment was in triplicate.


    (Only for Reference)
Animal Research:

[2]

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  • Animal Models: Wistar rats and White Leghorn chickens
  • Dosages: 62.5 mg/kg/day; 125 mg/kg/day
  • Administration: orally by crop tube
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 45 mg/mL (199.85 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 225.16
Formula

C8H7N3O5

CAS No. 67-45-8
Storage powder
in solvent
Synonyms N/A
Smiles C1COC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID