Home Microbiology Bacterial chemical Furazolidone

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Furazolidone Bacterial chemical

Cat.No.S4528

Furazolidone (Furoxone) is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.This compound can be used to induce animal models of Cardiomyopathy.
Furazolidone Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 225.16

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S452801 DMSO]45 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.91%
99.91

Chemical Information, Storage & Stability

Molecular Weight 225.16 Formula

C8H7N3O5

 Storage (From the date of receipt)
CAS No. 67-45-8 Download SDF Storage of Stock Solutions

Synonyms Furoxone Smiles C1COC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (199.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

Furazolidone displays potent antiproliferative properties at submicromolar concentrations and induces apoptosis in AML cell lines. This compound treatment of certain AML cells induces myeloid cell differentiation by morphology and flow cytometry for CD11b expression, resulting in increased stability of tumor suppressor p53 protein in AML cells[1].
In vivo

Furazolidone accelerates its own metabolism in the chicken by induction of the activity of CPR whereas no effect is observed in the rat[2].
References

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