Home Microbiology Bacterial chemical Furazolidone For research use only.

Furazolidone

Synonyms: Furoxone

Furazolidone(Furoxone) is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.

Furazolidone Chemical Structure

Furazolidone Chemical Structure

CAS: 67-45-8

Selleck's Furazolidone has been cited by 1 publication

Purity & Quality Control

Batch: S452801 DMSO] 45 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.91%
99.91

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Biological Activity

Description Furazolidone(Furoxone) is a synthetic nitrofuran derivative with bactericidal or bacteriostatic activity when used against Gram-positive and Gram-negative bacteria.
In vitro
In vitro

Furazolidone displays potent antiproliferative properties at submicromolar concentrations and induces apoptosis in AML cell lines. Furazolidone treatment of certain AML cells induces myeloid cell differentiation by morphology and flow cytometry for CD11b expression, resulting in increased stability of tumor suppressor p53 protein in AML cells[1].
Cell Research Cell lines The leukemic cells(Kasumi-1, NB4 and MolM-13)
Concentrations from 1 µM to 50 µM
Incubation Time 24, 48 and 72 hours
Method

Leukemic cells are seeded in 96-well culture plates at a density of 1 or 2×104 viable cells/100 µl/well in triplicates and are treated for 24, 48, and 72 hours with an incremental concentration of FZD ranging from 1 µM to 50 µM. Colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation assay is used to determine the cytotoxicity. The optical density at 492 nm is measured using a Multiskan Ascent® microplate photometer. IC50 values are determined by MTS assay when cells are treated with FZD for 72 hours and calculated with GraphPad Prism 5. Each experiment was in triplicate.
In Vivo
In vivo

FZ accelerates its own metabolism in the chicken by induction of the activity of CPR whereas no effect is observed in the rat[2].
Animal Research Animal Models Wistar rats and White Leghorn chickens
Dosages 62.5 mg/kg/day; 125 mg/kg/day
Administration orally by crop tube

Chemical Information & Solubility

Molecular Weight 225.16 Formula

C8H7N3O5
CAS No. 67-45-8 SDF Download Furazolidone SDF
Smiles C1COC(=O)N1N=CC2=CC=C(O2)[N+](=O)[O-]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 45 mg/mL ( (199.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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