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FABPs ligand 6 (MF6)

Cat.No.E6614

FABPs ligand 6 (MF6) is a potent dual inhibitor of FABP5 and FABP7 with KD values of 874 nM and 20 nM, respectively. It rescues mitochondrial function and mitigates FABP5/FABP7-mediated injury, demonstrating potential therapeutic effects in multiple sclerosis (MS).
FABPs ligand 6 (MF6) Chemical Structure

Chemical Structure

Molecular Weight: 458.52

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Quality Control

Batch: E661401 DMSO]92 mg/mL]false]Ethanol]6 mg/mL]false]Water]Insoluble]false Purity: 96.86%
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96.86

Solubility

In vitro
Batch:

DMSO : 92 mg/mL (200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 6 mg/mL

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 458.52 Formula

C28H27FN2O3

 Storage (From the date of receipt)
CAS No. 2988135-14-2 Download SDF Storage of Stock Solutions

Synonyms MF6 Smiles CC(C)C1=CC=C(N2C(C3=CC=CC=C3)=CC(C4=C(OCCCC(O)=O)C=CC(F)=C4)=N2)C=C1

Mechanism of Action

In vivo

MF 6 (1 mg/kg; i.g.; daily for 4 weeks) improves the severity of EAE (experimental autoimmune encephalomyelitis) and attenuates oxidative levels and the inflammatory response.
References

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