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Technical Data
| Formula | C24H18ClN3O3 |
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| Molecular Weight | 431.87 | CAS No. | 1219739-36-2 | |
| Solubility (25°C)* | In vitro | DMSO | 12 mg/mL (27.78 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. | |
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| In vitro | EX229 activates AMPK in incubated rat epitrochlearis skeletal muscle and incubation of rat skeletal muscle with ex229 increases glucose uptake. The stimulation of skeletal muscle glucose uptake by ex229 is PI3K/PKB-independent, while AMPK-dependent. ex229 increases fatty acid oxidation and glucose uptake in L6 myotubes[1]. |
Protocol (from reference)
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References
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Selleck's ex229 (compound 991) has been cited by 8 publications
| Redefining the role of AMPK in autophagy and the energy stress response [ Nat Commun, 2023, 14(1):2994] | PubMed: 37225695 |
| Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons [ bioRxiv, 2023, 2023.03.25.534233] | PubMed: 36993655 |
| [Fuyu Decoction improves ventricular remodeling in rats with heart failure by inhibiting AMPK/mTOR pathway-mediated autophagy] [ Nan Fang Yi Ke Da Xue Xue Bao, 2023, 43(3):466-473] | PubMed: 37087593 |
| Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha [ Mol Cell, 2022, S1097-2765(22)01058-9] | PubMed: 36384136 |
| IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells [ iScience, 2022, 25(8):104806] | PubMed: 35992082 |
| Liver kinase B1 (LKB1) in murine erythroid progenitors modulates erythropoietin setpoint in association with maturation control [ Blood Cells Mol Dis, 2022, 97:102688] | PubMed: 35717902 |
| Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. [ Cell Rep, 2019, 29(10):3331-3348] | PubMed: 31801093 |
| To ameriorate the post-infarction heart failure in rats with a traditional Chinese medicine, Wenyang-Yiqi recipe, and to analyze its pharmacological mechanism by AMPK-mediated mitochondrial autophagy [ CHINESE JOURNAL OF COMPARATIVE MEDICINE, 2019, 29(12): 39-44] | PubMed: None |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.