CAS No. 550999-74-1

Batch: Purity:99.34
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Encenicline (EVP-6124) hydrochloride Chemical Structure
Chemical Structure
Check the Encenicline (EVP-6124) hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 550999-74-1
Molecular Formula

C16H17ClN2OS.ClH
Molecular Weight (MW) 357.3
SMILES Cl.ClC1=C2SC(=CC2=CC=C1)C(=O)NC3CN4CCC3CC4

Ordering Information

Biological Activity

Encenicline (EVP-6124) hydrochloride is a selective partial agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR). By selectively potentiating endogenous acetylcholine-mediated responses at α7 nAChRs, it enhances central cholinergic pathway signaling and promotes synaptic plasticity. This activation facilitates synaptic transmission and improves cognitive functions, including memory performance, in preclinical models of cognitive deficit. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (198.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 35 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.