Home Metabolism Vitamin inhibitor Eldecalcitol

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Eldecalcitol Vitamin inhibitor

Cat.No.E0440

Eldecalcitol(ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3) is an orally active vitamin D₃ analogue that inhibits bone resorption while promoting bone formation, increasing bone mineral density, and is used clinically for osteoporosis. It also exhibits anti-tumor activity, inhibiting cancer cell proliferation and migration and inducing apoptosis, at least in part via suppression of glutathione peroxidase-1 (GPX1).
Eldecalcitol Vitamin inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 490.72

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Quality Control

Batch: E044001 DMSO]98 mg/mL]false]Ethanol]98 mg/mL]false]Water]Insoluble]false Purity: 99.82%
99.82

Solubility

In vitro
Batch:

DMSO : 98 mg/mL (199.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 98 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 490.72 Formula

C₃₀H₅₀O₅

 Storage (From the date of receipt) 3 years-20°C(in the dark) powder
CAS No. 104121-92-8 Download SDF Storage of Stock Solutions

Mechanism of Action

References

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