CAS No. 400827-46-5

Batch: Purity:99.98
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Ceftaroline Fosamil Chemical Structure
Chemical Structure
Check the Ceftaroline Fosamil product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 400827-46-5
Molecular Formula

C24H25N8O10PS4
Molecular Weight (MW) 744.74
SMILES CCO\N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(O)=O)SC3=NC(=CS3)C4=CC=[N+](C)C=C4)C5=NSC(=N5)N[P](O)(O)=O.CC([O-])=O

Ordering Information

Biological Activity

Ceftaroline fosamil is a prodrug of ceftaroline, an advanced-generation cephalosporin antibiotic that targets bacterial penicillin-binding proteins (PBPs), including PBP2a in methicillin-resistant Staphylococcus aureus (MRSA) and PBP2x in Streptococcus pneumoniae. By binding to PBPs, it inhibits peptidoglycan cross-linking during bacterial cell wall synthesis, leading to cell wall disruption and bactericidal activity against Gram-positive pathogens.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 73 mg/mL (98.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.