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Technical Data
| Formula | C18H15Cl2N5O5S3 |
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| Molecular Weight | 548.44 | CAS No. | 56187-47-4 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (182.33 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Cefazedone (Refosporen, Cefazedonum) is a semisynthetic first-generation cephalosporin with antibacterial activity. | ||
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| In vitro | Ceftezole exhibited potent α-glucosidase inhibitory activity. In in vitro α-glucosidase assays, ceftezole was shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a Ki value of 5.78×10−7 M when the enzyme mixture was pretreated with ceftezole[2]. | ||
| In vivo | In mice, dogs, and rabbits, cefazedone produced high and prolonged serum levels. It does not penetrate the CSF or brain tissue[1]. Ceftezole inhibits the blood glucose increase that occurs following glucose uptake. Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA were also slightly decreased compared to controls following ceftezole treatment. It exhibits anti-diabetic activity in vivo[2]. |
Protocol (from reference)
| Animal Study: |
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References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.