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Diaveridine DHFR inhibitor

Name: Diaveridine
Brand: Selleck Chemicals
SKU: S5200
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S5200

Diaveridine (AI3-23935, CCRIS-3784) is a coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.

Chemical Structure

Molecular Weight: 260.29

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S520001 DMSO]25 mg/mL]false]]]false]]]false Purity: 99.82%

99.82

Related Targets	P450 (e.g. CYP17) Dehydrogenase PDE phosphatase PPAR HSP (HSP90) Vitamin Transferase Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase Serine/threonin kinase Lipoxygenase Phospholipase (e.g. PLA) Retinoid Receptor DPP ACE Peroxidases Fatty Acid Synthase FXR HMG-CoA Reductase Carbonic Anhydrase Lipase Decarboxylase IDO/TDO Hydroxylase PCSK9 OXPHOS ROR Acyltransferase
Related Products	Calcium Folinate

Chemical Information, Storage & Stability

Molecular Weight	260.29	Formula	C₁₃H₁₆N₄O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	5355-16-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AI3-23935, CCRIS-3784			Smiles	COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC

Solubility

In vitro
Batch:

DMSO : 25 mg/mL ( (96.04 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	DHFR ^[1]
In vitro	Diaveridine (DVD) is a pyrimethamine analogue, a folic acid antagonist. It is also used as an antibacterial agent, especially for the respiratory and gastrointestinal tract infections in humans and animals. This compound is genotoxic in mammalian cells in vitro and in vivo^[1].
In vivo	Acute tests indicate that the diaveridine has a high LD50 value and suggests a wide margin of safety for therapeutic doses^[1].
References	https://pubmed.ncbi.nlm.nih.gov/26397222/

Tech Support

Handling Instructions

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