Diaveridine

Catalog No.S5200 Synonyms: AI3-23935, CCRIS-3784

For research use only.

Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.

Diaveridine Chemical Structure

CAS No. 5355-16-8

Purity & Quality Control

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Biological Activity

Description Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
Targets
DHFR [1]
In vitro

Diaveridine (DVD) is a pyrimethamine analogue, a folic acid antagonist. It is also used as an antibacterial agent, especially for the respiratory and gastrointestinal tract infections in humans and animals. Diaveridine is genotoxic in mammalian cells in vitro and in vivo[1].

In vivo Acute tests indicate that the diaveridine has a high LD50 value and suggests a wide margin of safety for therapeutic doses[1].

Protocol (from reference)

Animal Research:

[1]

  • Animal Models: Female and male Sprague Dawley rats and ICR mice
  • Dosages: 780, 1131, 1640, 2378, 3448 and 5000 mg/kg for rats and 12, 452, 656, 951, 1379 and 2000 mg/kg for mice
  • Administration: oral

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 260.29
Formula

C13H16N4O2

CAS No. 5355-16-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles COC1=C(C=C(C=C1)CC2=CN=C(N=C2N)N)OC

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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