CAS No. 210302-17-3

Batch: Purity:99.95
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BAM 15 Chemical Structure
Chemical Structure
Check the BAM 15 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-N,6-N-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
CAS Number 210302-17-3
Molecular Formula

C16H10F2N6O
Molecular Weight (MW) 340.29
SMILES C1=CC=C(C(=C1)NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F)F
InChIKey OEGJBRZAJRPPHL-UHFFFAOYSA-N

Ordering Information

Biological Activity

BAM 15 is a novel mitochondrial protonophore uncoupler and potent activator of AMPK signaling. By stimulating mitochondrial respiration without depolarizing the plasma membrane, it dissipates the proton gradient across the inner mitochondrial membrane, thereby reducing oxidative stress and activating cellular energy sensing pathways. Consequently, BAM 15 protects against acute renal ischemia-reperfusion injury, reduces cold-induced microtubule damage, and attenuates apoptosis in stem cell-derived tissues. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.