CAS No. 2921-14-4
| CAS Number | 2921-14-4 | |
|---|---|---|
| Molecular Formula |
C2H5NO3.1/2HCl |
|
| Molecular Weight (MW) | 109.3 | |
| SMILES | C(C(=O)O)ON.C(C(=O)O)ON.Cl |
AOA (Aminooxyacetic acid) hemihydrochloride is an inhibitor of pyridoxal phosphate-dependent enzymes, including aminobutyrate aminotransferase and cystathionine β-synthase (CBS). Furthermore, AOA hemihydrochloride effectively inhibits the malate-aspartate shuttle (MAS) by targeting transaminase activity. Disruption of these pathways alters amino acid and polyamine metabolism, suppresses mitochondrial respiration, and inhibits proliferation across multiple cancer cell lines. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
22 mg/mL
(201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 22 mg/mL |
| Ethanol | 6 mg/mL |
| DMSO |
21 mg/mL
(192.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 21 mg/mL |
| Ethanol | 21 mg/mL |
| DMSO |
21 mg/mL
(192.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- AOA (Aminooxyacetic acid) hemihydrochloride Clinical Trials
- AOA (Aminooxyacetic acid) hemihydrochloride Solubility in DMSO
- AOA (Aminooxyacetic acid) hemihydrochloride Stock Solution
- AOA (Aminooxyacetic acid) hemihydrochloride Storage
- AOA (Aminooxyacetic acid) hemihydrochloride Stability
- AOA (Aminooxyacetic acid) hemihydrochloride Molecular Weight
- AOA (Aminooxyacetic acid) hemihydrochloride SMILES
- AOA (Aminooxyacetic acid) hemihydrochloride Chemical Structure (2D and 3D)
- AOA (Aminooxyacetic acid) hemihydrochloride SDS｜MSDS