Choose Your Country or Region

research use only

LY2835219 (Abemaciclib) Mesylate CDK4/6 inhibitor

Cat.No.S7158

Abemaciclib mesylate is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.

LY2835219 (Abemaciclib) Mesylate CDK inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 602.7

Jump to

Quality Control

Batch: Purity: 99.97%

99.97

Related Targets	HSP PD-1/PD-L1 ROCK Wee1 DNA/RNA Synthesis Microtubule Associated Ras KRas Aurora Kinase Casein Kinase
Other CDK Inhibitors	AS2863619 Ro-3306 SEL120 (SEL120-34A) hydrochloride INX-315 Tagtociclib (PF-07104091) PF-07220060 (CDK4/6-IN-6) AZD4573 ON123300 Enitociclib (BAY 1251152) Samuraciclib (ICEC0942) hydrochloride

Q&A of LY2835219 (Abemaciclib) Mesylate: Insights Rooted in Extensive Publications, Every Answer Cited

AI will take about 1 minute to answer this question... 0%

Solubility in DMSO or Water

In vitro
Batch:

Water : 100 mg/mL

DMSO : 24 mg/mL (39.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 13 mg/mL

The solubility data above are all experimental results (not literature values).

Water : 100 mg/mL

DMSO : 83 mg/mL (137.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 24 mg/mL

The solubility data above are all experimental results (not literature values).

Water : 100 mg/mL

Ethanol : 100 mg/mL

DMSO : 33 mg/mL (54.75 mM) Warmed with 60°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

The solubility data above are all experimental results (not literature values).

Water : 100 mg/mL

DMSO : 50 mg/mL (82.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 13 mg/mL

The solubility data above are all experimental results (not literature values).

Water : 100 mg/mL

DMSO : 33 mg/mL (54.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 4 mg/mL

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/ml (0.25mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Read more about LY2835219 (Abemaciclib) Mesylate solubility in DMSO or water

Search directly for a cell line, or select a cell line to find matched working concentrations

Read more about LY2835219 (Abemaciclib) Mesylate working concentrations for cell culture treatment

LY2835219 (Abemaciclib) Mesylate is a potent inhibitor of HIPK2 (0.45 ±0.12 µM), CDK4/CyclinD3 (7.8 nM), CDK6/CyclinD3 (55.5 nM). LY2835219 (Abemaciclib) Mesylate exhibits the greatest inhibitory potency toward CDK4/CyclinD3 (IC50 = 7.8 nM).

Read more about selectivity & specificity

Mechanism of Action

Information	LY2835219 (Abemaciclib) Mesylate is a potent, selective, and reversible ATP-competitive CDK4/6 inhibitor. It affects Rb/E2F signaling by blocking retinoblastoma protein phosphorylation, effectively inhibiting G1 to S phase cell cycle progression and tumor cell proliferation.
Read more about LY2835219 (Abemaciclib) Mesylate IC50 for cell-based and cell-free assays
Primary Applications and Mechanism of Action

Read more about LY2835219 (Abemaciclib) Mesylate Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight	602.7	Formula	C₂₇H₃₂F₂N₈.CH₄O₃S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1231930-82-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	LY2835219 mesylate			Smiles	CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O

Read more about storage & stability

Read more comparative analysis about LY2835219 (Abemaciclib) Mesylate

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Frequently Asked Questions

Question 1:
Is your product S7158 “mesylate salt form”?

Answer:
It is the mesylate salt form of our S7158 LY2835219.

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration _(start) x Volume _(start) = Concentration _(final) x Volume _(final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

Serial Dilutions

Concentration (start):

Dilution-folds:

Computed Result

C1=C0/X	C1:		LOG(C1):
C2=C1/X	C2:		LOG(C2):
C3=C2/X	C3:		LOG(C3):
C4=C3/X	C4:		LOG(C4):
C5=C4/X	C5:		LOG(C5):
C6=C5/X	C6:		LOG(C6):
C7=C6/X	C7:		LOG(C7):
C8=C7/X	C8:		LOG(C8):