Target Selectivity of LY2835219 (Abemaciclib) Mesylate

Key TargetIC50DescriptionReference
CDK4/CyclinD3 7.8 nM CDK4/CyclinD3 Kinase Assay Kit, luminescence measurement PMC11241330
CDK6/CyclinD3 55.5 nM CDK6/CyclinD3 Kinase Assay Kit, luminescence measurement PMC11241330
HIPK2 0.45 µM ADP-GloTM kinase assay PMC11597050
Check the LY2835219 (Abemaciclib) Mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Cell-free Assays (IC50/Ki) for LY2835219 (Abemaciclib) Mesylate

Key TargetIC50 (Cell-free)DescriptionReference
HIPK2 0.45 ±0.12 µM ADP-GloTM kinase assay Download PDF
CDK4/CyclinD3 7.8 nM CDK4/CyclinD3 Kinase Assay Kit, luminescence measurement Download PDF
CDK6/CyclinD3 55.5 nM CDK6/CyclinD3 Kinase Assay Kit, luminescence measurement Download PDF

Cell-based Assay (IC50) for LY2835219 (Abemaciclib) Mesylate

Cell TypeIC50 (Cell-based)DescriptionReference
MCF-7 57 μM Sulforhodamine-B method; dose–response curve-fitting models (GraphPad Prism software, version 5) Download PDF
MDA-MB-231 32 μM Sulforhodamine-B method; dose–response curve-fitting models (GraphPad Prism software, version 5) Download PDF
MDA-MB-468 61 μM Sulforhodamine-B method; dose–response curve-fitting models (GraphPad Prism software, version 5) Download PDF
MCF-7 0.01 µM MTS assay Download PDF
T47D 0.01 µM MTS assay Download PDF

Jump to