LY2835219 (Abemaciclib) Mesylate Solubility in DMSO

Size	Price	Qty
5mg	USD 270
25mg	USD 397

In Vitro Solubility

Batch:

All in vitro solubility values are batch-tested experimental data (non-literature values).

Solvent	Solubility & Note
Water	100 mg/mL
DMSO	24 mg/mL (39.82 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	13 mg/mL
Water	100 mg/mL
DMSO	83 mg/mL (137.71 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	24 mg/mL
Water	100 mg/mL
Ethanol	100 mg/mL
DMSO	33 mg/mL (54.75 mM) ; Warmed with 60°C water bath ; Ultrasonicated (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water	100 mg/mL
DMSO	50 mg/mL (82.96 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	13 mg/mL
Water	100 mg/mL
DMSO	33 mg/mL (54.75 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol	4 mg/mL

FAQ

Q: Why does a DMSO stock precipitate in media/saline?

A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.

How to fix it?

Preheat media/saline to 37°C.
Mix rapidly (pipette/vortex) upon addition.
For complex mixes, always add the aqueous phase last.
Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Check the LY2835219 (Abemaciclib) Mesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

Concentration Volume Mass	1 mg	5 mg	10 mg

Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.

Formulation for Animal Experiments

Batch:

Administration Route	Formulation Type	Formulation Details	Solubility	Preparation Method
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Injection	Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.150mg/mL (0.25mM)	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Oral Administration	Homogeneous suspensionCMC-NA	CMC-NA	≥5mg/mL	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

Recommended and Maximum Dosing Volumes for Animal Experiments

Other Animals:

🐁 In Vivo Formulation Calculator

Dosage: mg/kg

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Avg Wt: g

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Vol/Animal: μL

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Animals:

% DMSO

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% PEG300

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% Tween 80

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% ddH₂O

LY2835219 (Abemaciclib) Mesylate Solubility