CAS No. 1231930-82-7
Batch:
Purity:99.97
Chemical Structure
Check the
LY2835219 (Abemaciclib) Mesylate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine;methanesulfonic acid | |
|---|---|---|
| CAS Number | 1231930-82-7 | |
| Molecular Formula |
C27H32F2N8.CH4O3S |
|
| Molecular Weight (MW) | 602.7 | |
| SMILES | CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F.CS(=O)(=O)O | |
| InChIKey | NCJPFQPEVDHJAZ-UHFFFAOYSA-N |
Biological Activity
Abemaciclib Mesylate is a potent and selective inhibitor of CDK4 (IC50 2 nM) and CDK6. By blocking cyclin D interaction, it inhibits retinoblastoma (Rb) protein phosphorylation, resulting in G1 cell cycle arrest. This targeted disruption suppresses downstream signaling, blocking cell proliferation and effectively inhibiting tumor growth in multiple preclinical human cancer xenograft models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
24 mg/mL
(39.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 13 mg/mL |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
| DMSO |
33 mg/mL
(54.75 mM)
; Warmed with 60°C water bath
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| DMSO |
33 mg/mL
(54.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- LY2835219 (Abemaciclib) Mesylate Mechanism of Action: CDK4/6 Inhibition in Breast Cancer Cell Research
- LY2835219 (Abemaciclib) Mesylate Clinical Trials
- LY2835219 (Abemaciclib) Mesylate Working Concentration | Cell Culture | Treatment
- LY2835219 (Abemaciclib) Mesylate Solubility in DMSO
- LY2835219 (Abemaciclib) Mesylate Stock Solution
- LY2835219 (Abemaciclib) Mesylate Storage
- LY2835219 (Abemaciclib) Mesylate Stability
- LY2835219 (Abemaciclib) Mesylate Combination Database
- LY2835219 (Abemaciclib) Mesylate Molecular Weight
- LY2835219 (Abemaciclib) Mesylate SMILES
- LY2835219 (Abemaciclib) Mesylate Chemical Structure (2D and 3D)
- LY2835219 (Abemaciclib) Mesylate IC50 for Cell-based and Cell-free Assays
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- LY2835219 (Abemaciclib) Mesylate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.