LY2835219 (Abemaciclib) Mesylate is a potent, selective, and reversible ATP-competitive CDK4/6 inhibitor. It affects Rb/E2F signaling by blocking retinoblastoma protein phosphorylation, effectively inhibiting G1 to S phase cell cycle progression and tumor cell proliferation.
LY2835219 (Abemaciclib) Mesylate IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for LY2835219 (Abemaciclib) Mesylate Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.