CAS No. 6483-15-4

Batch: Purity:99.93
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Sophocarpine Chemical Structure
Chemical Structure
Check the Sophocarpine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadec-4-en-6-one
CAS Number 6483-15-4
Molecular Formula

C15H22N2O
Molecular Weight (MW) 246.35
SMILES C1CC2CN3C(CC=CC3=O)C4C2N(C1)CCC4
InChIKey AAGFPTSOPGCENQ-JLNYLFASSA-N

Biological Activity

Sophocarpine is a natural quinolizidine alkaloid that functions as an inhibitor of human ether-à-go-go-related gene (HERG) potassium channels. By targeting HERG channels, it concentration-dependently suppresses cardiac potassium currents and accelerates channel inactivation dynamics without altering channel activation. Blockade or dysfunction of HERG channels directly modulates cardiac cellular repolarization pathways and regulates voltage-gated ion conductance across cell membranes. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49 mg/mL (198.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 49 mg/mL
Water 6 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Sanguinetti MC, et al. Nature. 2006;440(7083):463-9.

[2] Vandenberg JI, et al. Physiol Rev. 2012;92(3):1393-478.

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Note: Technical data last updated: Sep 1, 2026.