CAS No. 478-43-3

Batch: Purity:99.73
Check CoA
Rheic Acid Chemical Structure
Chemical Structure
Check the Rheic Acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
CAS Number 478-43-3
Molecular Formula

C15H8O6
Molecular Weight (MW) 284.22
SMILES C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O
InChIKey FCDLCPWAQCPTKC-UHFFFAOYSA-N

Ordering Information

Biological Activity

Rheic acid is an anthraquinone natural product that acts as an inhibitor of mRNA N6-methyladenine demethylase (FTO) and AlkB repair enzymes. By blocking demethylase activity, it modulates RNA m6A modification levels and impairs nucleic acid repair pathways. Consequently, rheic acid displays anti-inflammatory and antitumor activities, improves glucose tolerance, restores first-phase insulin secretion, and protects pancreatic islet function in metabolic dysfunction models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.