FTO

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FTO Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S2400 Rheic Acid Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.
Cell Chem Biol, 2016, 23(3):415-25
S4295 Meclofenamate Sodium Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
Front Oncol, 2022, 12:817584
Nature, 2019, 573(7775):539-545
S6291 FB23 FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
Oncogene, 2022, 41(20):2860-2872
S8837 FB23-2 FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N6-methyladenosine (m6A) demethylase activity with IC50 of 2.6 μM.
S9876 Dac51 Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation.
S9946New Bisantrene (CS1)

Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity. Bisantrene also is a potent and selective FTO inhibitor.

S2400 Rheic Acid Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N6-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.
Cell Chem Biol, 2016, 23(3):415-25
S4295 Meclofenamate Sodium Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate Sodium is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.
Front Oncol, 2022, 12:817584
Nature, 2019, 573(7775):539-545
S6291 FB23 FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. FB23 directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.
Oncogene, 2022, 41(20):2860-2872
S8837 FB23-2 FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N6-methyladenosine (m6A) demethylase activity with IC50 of 2.6 μM.
S9876 Dac51 Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation.
S9946New Bisantrene (CS1)

Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity. Bisantrene also is a potent and selective FTO inhibitor.

S9946New Bisantrene (CS1)

Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity. Bisantrene also is a potent and selective FTO inhibitor.

Tags: FTO inhibitor|FTO agonist|FTO activator|FTO inducer|FTO antagonist|FTO signaling pathway|FTO assay kit