FTO

Other Methylation Related Inhibitors

EZH2 PRMT MAT2A LSD1 JMJD G9a/GLP SETD MLL COMT DOT1

Cat.No.	Product Name	Information	Product Use Citations
S8837	FB23-2	FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits this compound's N⁶-methyladenosine (m⁶A) demethylase activity with IC50 of 2.6 μM.	Nat Commun, 2025, 16(1):2925 J Adv Res, 2025, S2090-1232(25)00038-4 Cell Death Dis, 2025, 16(1):222
S9876	Dac51	Dac51 is a potent FTO inhibitor with an IC50 of 0.4 μM for inhibiting FTO demethylation.	Nat Commun, 2025, 16(1):1519 Nature Communications, 2025, 1519 Biomedicines, 2025, 1653
S2400	Rheic Acid	Rhein (Monorhein, NSC 38629, Rheinic) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein is an FTO (mRNA N⁶-methyladenine demethylase) inhibitor and also inhibits AlkB repair enzymes.	Animals (Basel), 2024, 14(16)2434 Cell Chem Biol, 2016, 23(3):415-25
S6291	FB23	FB23 is a potent and selective inhibitor of FTO demethylase with IC50 of 60 nM. This compound directly binds to FTO and selectively inhibits FTO's mRNA N6-methyladenosine (m6A) demethylase activity.	International Journal of Biological Sciences, 2025, 7063-7085 Oncogene, 2022, 41(20):2860-2872 Oncogene, 2022, 2860-2872
S9946	Bisantrene (CS1)	Bisantrene (CS1, NSC-337766, CL 216,942) is an anthracene derivative with anti-tumor activity and a potent and selective FTO inhibitor.
S4295	Meclofenamate Sodium	Meclofenamate Sodium(CI 583) is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. This compound is a non-selective gap-junction blocker and a highly selective inhibitor of fat mass and obesity-associated (FTO) enzyme inhibitor.	Biomaterials, 2025, 319:123168 Cancer Metab, 2025, 13(1):32 Adv Sci (Weinh), 2023, e2307206.