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MK-2206 Dihydrochloride SDS | MSDS
1.PRODUCT AND COMPANY IDENTIFICATION
Product identifier
- Product Name: MK-2206 Dihydrochloride
- Catalog Number: S1078
- CAS Number: 1032350-13-2
- IUPAC Name: 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
Relevant identified uses and uses advised against
- Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
- Uses advised against: Not for pharmaceutical, household, or other unapproved uses.
Details of the supplier
- Company : Selleck Chemicals
- TollFree : +1 877 796-6397
- Tel : +1 832 582-8158
- Fax : +1 832 582-8590
Emergency telephone number
- Emergency phone #: +1 832 582-8158
2. HAZARDS IDENTIFICATION
2.1 Classification of the substance or mixture
This substance does not meet the classification criteria of the EC Directives 67/548/EEC, 1999/45/EC, or 1272/2008.
2.2 Label elements
The product does not require labeling in accordance with EC directives or respective national laws.
2.3 Other hazards
None.
3. COMPOSITION/INFORMATION ON INGREDIENTS
3.1 Substances
- Product Name: MK 2206 dihydrochloride
- Formula: C25H21N5O.2HCl
- Molecular Weight: 480.39
- CAS Number: 1032350-13-2
- Name: 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one
4. FIRST AID MEASURES
4.1 Description of first aid measures
- General advice: Consult a physician and present this safety data sheet.
- If inhaled: Move person to fresh air and monitor breathing. If breathing is difficult, give oxygen; if breathing stops, provide artificial respiration. Consult a physician.
- In case of skin contact: Immediately wash skin with soap and copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Consult a physician.
- In case of eye contact: Flush eyes with copious amounts of water for at least 15 minutes and consult a physician.
- If swallowed: Rinse mouth with water. Do not induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The chemical, physical, and toxicological properties have not been thoroughly investigated.
4.3 Indication of immediate medical attention and special treatment needed
Immediate medical attention is required. Show this safety data sheet to the attending physician.
5. FIRE-FIGHTING MEASURES
5.1 Extinguishing media
Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Combustion may emit toxic fumes.
5.3 Precautions for fire-fighters
Wear self-contained breathing apparatus and suitable protective clothing to prevent contact with skin and eyes.
6. ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment and emergency procedures
Do not take action without suitable protective clothing. Evacuate personnel to safe areas and ensure adequate ventilation. Avoid breathing vapors, mist, powder, or gas.
6.2 Environmental precautions
Do not allow the product to enter drains.
6.3 Methods and materials for containment and cleaning up
Cover spillage with suitable absorbent material. Sweep up the powder and place it in an appropriate container for disposal as described in Section 13.
6.4 Reference to other sections
Refer to Section 8 for personal protective equipment and Section 13 for disposal instructions.
7. HANDLING AND STORAGE
7.1 Precautions for safe handling
Use in a chemical fume hood with an independent air supply. Avoid inhalation and contact with eyes, skin, and clothing. Avoid the formation of powder and aerosols. Use in a well-ventilated area and keep away from sources of ignition.
7.2 Conditions for safe storage, including any incompatibilities
Store in a cool, well-ventilated area away from direct sunlight. Keep the container tightly sealed until use. Recommended storage temperature is -20°C.
7.3 Specific end uses
Use in a laboratory fume hood where possible. Refer to the employer's COSHH risk assessment.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Contains no substances with occupational exposure limit values.
8.2 Exposure controls
- Appropriate engineering controls: Use in a fume hood. Ensure the laboratory is equipped with a safety shower and eye wash station.
- Eye/face protection: Use appropriate safety glasses.
- Skin protection: Use chemical-resistant gloves (minimum requirement BS EN 374:2003). Inspect gloves before use and wash hands thoroughly after handling.
- Body protection: Wear appropriate protective clothing.
- Respiratory protection: Use a suitable respirator if a risk assessment indicates it is necessary.
9. PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
- Appearance: Yellow powder
- Odor: N/A
- Odor threshold: N/A
- pH: N/A
- Melting / freezing point: N/A
- Boiling point / range: N/A
- Flash point: N/A
- Evaporation rate: N/A
- Flammability (solid, gas): N/A
- Upper / lower flammability or explosive limits: N/A
- Vapor pressure: N/A
- Vapor density: N/A
- Relative density: N/A
- Solubility(ies): Soluble to 50 mM in DMSO
- Partition coefficient: N/A
- Auto-ignition temperature: N/A
- Decomposition temperature: N/A
- Viscosity: N/A
- Explosive properties: N/A
- Oxidising properties: N/A
9.2 Other safety information
N/A.
10. STABILITY AND REACTIVITY
10.1 Reactivity
Stable under recommended transport or storage conditions.
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Hazardous reactions will not occur under normal transport or storage conditions. Decomposition may occur upon exposure to specific conditions or incompatible materials.
10.4 Conditions to avoid
Heat and moisture.
10.5 Incompatible materials
Strong acids/alkalis, strong oxidising/reducing agents.
10.6 Hazardous decomposition products
In combustion, may emit toxic fumes. No known decomposition information.
11. TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
- Acute Toxicity: N/A.
- Skin corrosion/irritation: Classification criteria not met.
- Serious eye damage/irritation: Classification criteria not met.
- Respiratory or skin sensitization: Classification criteria not met.
- Germ cell mutagenicity: Classification criteria not met.
- Carcinogenicity: Classification criteria not met.
- Reproductive toxicity: Classification criteria not met.
- STOT - single exposure: Classification criteria not met.
- STOT - repeated exposure: Classification criteria not met.
- Aspiration hazard: Classification criteria not met.
Symptoms / Routes of exposure
- Inhalation: Possible irritation of the throat with a feeling of tightness in the chest.
- Ingestion: Possible irritation of the throat.
- Skin: Possible mild irritation at the site of contact.
- Eyes: Possible irritation and redness.
- Delayed / Immediate Effects: No known symptoms.
Additional Information
- RTECS No: Not available.
- Exposure may cause irritation of eyes, mucous membranes, upper respiratory tract, and skin. Toxicological properties have not been fully investigated.
12. ECOLOGICAL INFORMATION
12.1 Toxicity
No specific data provided for this section.
12.2 Persistence and degradability
No specific data provided for this section.
12.3 Bioaccumulative potential
No specific data provided for this section.
12.4 Mobility in soil
No specific data provided for this section.
12.5 Results of PBT and vPvB assessment
No specific data provided for this section.
12.6 Other adverse effects
No specific data provided for this section.
13. DISPOSAL CONSIDERATIONS
13.1 Waste treatment methods
- Product: Transfer to a suitable container and arrange for collection by a specialized disposal company in accordance with national legislation.
- Contaminated packaging: Dispose of in a regulated landfill site or via other methods for hazardous or toxic wastes in accordance with national legislation.
14. TRANSPORT INFORMATION
14.1 UN-Number
Does not meet the criteria for classification as hazardous for transport.
14.2 UN proper shipping name
Does not meet the criteria for classification as hazardous for transport.
14.3 Transport hazard class(es)
Does not meet the criteria for classification as hazardous for transport.
14.4 Packaging group
Does not meet the criteria for classification as hazardous for transport.
14.5 Environmental hazards
This product is not classified as environmentally hazardous according to the UN Model Regulations, nor a marine pollutant according to the IMDG Code.
14.6 Special precautions for users
N/A.
15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
N/A
California Proposition 65
Not applicable
15.2 Chemical safety assessment
A Chemical Safety Assessment has not been made for this product.
16. OTHER INFORMATION
Revision Date: 2026/07/02
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.