Print

Download

Navitoclax (ABT-263) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: Navitoclax (ABT-263)
  • Catalog Number: S1001
  • CAS Number: 923564-51-6
  • IUPAC Name: 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. HAZARDS IDENTIFICATION

This substance is not classified as hazardous according to EC Directives 67/548/EEC, 1999/45/EC, or 1272/2008. Consequently, the product does not require specific labeling under current EC directives or national legislation. There are no other identified hazards.

3. COMPOSITION/INFORMATION ON INGREDIENTS

The product is a substance identified as ABT 263 (Navitoclax).

  • Chemical Name: 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide
  • Molecular Weight: 974.62
  • CAS Number: 923564-51-6

4. FIRST AID MEASURES

  • General Advice: Consult a physician and present this safety data sheet.
  • Inhalation: Move the individual to fresh air and monitor breathing. If breathing is difficult, administer oxygen; if breathing has stopped, perform artificial respiration and seek medical attention.
  • Skin Contact: Wash the affected area with soap and water for at least 15 minutes. Remove contaminated clothing and shoes, ensuring they are laundered before reuse. Consult a physician.
  • Eye Contact: Flush eyes with copious amounts of water for at least 15 minutes and consult a physician.
  • Ingestion: Rinse the mouth with water. Do not induce vomiting unless instructed by medical personnel. Never give anything by mouth to an unconscious person. Consult a physician.
  • Symptoms: The chemical, physical, and toxicological properties have not been fully investigated.
  • Medical Attention: Immediate medical attention is required; show this SDS to the attending physician.

5. FIRE-FIGHTING MEASURES

  • Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide.
  • Special Hazards: Combustion may result in the emission of toxic fumes.
  • Precautions for Firefighters: Wear self-contained breathing apparatus and suitable protective clothing to prevent contact with skin and eyes.

6. ACCIDENTAL RELEASE MEASURES

  • Personal Precautions: Use suitable protective equipment. Evacuate personnel to safe areas and ensure adequate ventilation. Avoid breathing vapors, mist, powder, or gas.
  • Environmental Precautions: Prevent the product from entering drains.
  • Cleanup Methods: Cover the spill with suitable absorbent material. Sweep up the powder and place it in an appropriate container for disposal according to Section 13.

7. HANDLING AND STORAGE

  • Handling: Use within a chemical fume hood with an independent air supply. Avoid inhalation and contact with eyes, skin, and clothing. Prevent the formation of powder and aerosols. Ensure the area is well-ventilated and kept away from ignition sources.
  • Storage: Store in a cool, well-ventilated area away from direct sunlight. Keep containers tightly sealed. The recommended storage temperature is -20°C.
  • Specific End Uses: Use in a laboratory fume hood where possible, following the employer's COSHH risk assessment.

8. EXPOSURE CONTROLS/PERSONAL PROTECTION

  • Control Parameters: Contains no substances with established occupational exposure limit values.
  • Engineering Controls: Use in a fume hood. Ensure safety showers and eye wash stations are available.
  • Personal Protective Equipment:
    • Eye/Face: Use appropriate safety glasses.
    • Skin: Use chemical-resistant gloves (minimum BS EN 374:2003). Inspect gloves before use and wash hands thoroughly.
    • Body: Wear appropriate protective clothing.
    • Respiratory: Use a suitable respirator if a risk assessment indicates it is necessary.

9. PHYSICAL AND CHEMICAL PROPERTIES

  • Appearance: Off White powder
  • Solubility: Soluble to 100 mM in DMSO
  • Vapor Pressure/Density: N/A
  • Odor/Threshold: N/A
  • pH: N/A
  • Melting/Freezing Point: N/A
  • Boiling Point/Range: N/A
  • Flash Point: N/A
  • Evaporation Rate: N/A
  • Flammability: N/A
  • Upper/Lower Explosive Limits: N/A
  • Relative Density: N/A
  • Partition Coefficient: N/A
  • Auto-ignition Temperature: N/A
  • Decomposition Temperature: N/A
  • Viscosity: N/A
  • Explosive/Oxidizing Properties: N/A

10. STABILITY AND REACTIVITY

  • Reactivity: Stable under recommended transport or storage conditions.
  • Chemical Stability: Stable under recommended storage conditions.
  • Hazardous Reactions: Will not occur under normal conditions. Decomposition may occur if exposed to specific conditions or incompatible materials.
  • Conditions to Avoid: Heat and moisture.
  • Incompatible Materials: Strong acids/alkalis and strong oxidizing/reducing agents.
  • Hazardous Decomposition Products: May emit toxic fumes during combustion.

11. TOXICOLOGICAL INFORMATION

  • Acute Toxicity: N/A.
  • Skin/Eye/Sensitization: Classification criteria are not met based on available data.
  • Mutagenicity/Carcinogenicity/Reproductive Toxicity: Classification criteria are not met based on available data.
  • STOT (Single/Repeated): Classification criteria are not met based on available data.
  • Aspiration Hazard: Classification criteria are not met based on available data.
  • Routes of Exposure: Inhalation may cause throat irritation and chest tightness; ingestion may cause throat irritation; skin contact may cause mild irritation; eye contact may cause irritation and redness.
  • Additional Information: RTECS No: CV2467355. Exposure may irritate mucous membranes and the respiratory tract. Properties have not been fully investigated.

12. ECOLOGICAL INFORMATION

  • Toxicity: N/A.
  • Persistence and Degradability: N/A.
  • Bioaccumulative Potential: N/A.
  • Mobility in Soil: N/A.
  • PBT and vPvB Assessment: N/A.
  • Other Adverse Effects: N/A.

13. DISPOSAL CONSIDERATIONS

  • Product: Transfer to a suitable container and arrange for collection by a specialized disposal company in accordance with national legislation.
  • Contaminated Packaging: Dispose of in a regulated landfill or via other methods for hazardous/toxic waste in accordance with national legislation.

14. TRANSPORT INFORMATION

The product is classified according to UN Model Regulations, IMDG Code, ADR, RID, and IATA.

  • UN Number/Proper Shipping Name: Does not meet criteria for classification as hazardous for transport.
  • Transport Hazard Class/Packaging Group: Does not meet criteria for classification as hazardous for transport.
  • Environmental Hazards: Not classified as environmentally hazardous or a marine pollutant.
  • Special Precautions: N/A.

15. REGULATORY INFORMATION

This safety datasheet complies with the requirements of Regulation (EC) No. 453/2010.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
N/A
California Proposition 65
Not applicable
15.2 Chemical safety assessment
A Chemical Safety Assessment has not been made for this product.

16. OTHER INFORMATION

Revision Date: 2026/05/28
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

Jump to: