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Glycolic acid Tyrosinase inhibitor

Cat.No.S6272

Glycolic acid (dicarbonous acid, hydroxyacetic acid, hydroacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, this compound is often used in skin care products, most often as a chemical peel. It is an inhibitor of tyrosinase, suppressing melanin formation and lead to a lightening of skin colour.
Glycolic acid Tyrosinase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 76.05

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S627201 DMSO]15 mg/mL]false]Water]10 mg/mL]false]]]false Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 76.05 Formula

C2H4O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 79-14-1 -- Storage of Stock Solutions

Synonyms dicarbonous acid, hydroxyacetic acid, hydroacetic acid Smiles C(C(=O)O)O

Solubility

In vitro
Batch:

DMSO : 15 mg/mL (197.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 10 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05362500 Completed
Melasma
Combined Military Hospital Abbottabad
 June 1 2021 Phase 1
NCT03437265 Completed
Pharmacokinetic
Norgine|Quotient Sciences
 September 3 2020 Phase 1
NCT01289171 Completed
Flat Warts|HIV
University of Pennsylvania|NeoStrata Company Inc.|Penn Center for AIDS Research (CFAR)
 January 2009 Not Applicable

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