Home Proteases Tyrosinase inhibitor Deoxyarbutin

research use only

Deoxyarbutin Tyrosinase inhibitor

Cat.No.S4132

DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.
Deoxyarbutin Tyrosinase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 194.23

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S413201 DMSO]39 mg/mL]false]Ethanol]39 mg/mL]false]Water]Insoluble]false Purity: 99.32%
99.32

Chemical Information, Storage & Stability

Molecular Weight 194.23 Formula

C11H14O3

 Storage (From the date of receipt)
CAS No. 53936-56-4 Download SDF Storage of Stock Solutions

Synonyms D-arbutin,D-Arb Smiles C1CCOC(C1)OC2=CC=C(C=C2)O

Solubility

In vitro
Batch:

DMSO : 39 mg/mL ( (200.79 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 39 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Features
More effective than hydroquinone in inhibiting mushroom tyrosinase.
Targets/IC50/Ki
tyrosinase [1]
50 nM
In vitro

DeoxyArbutin demonstrates effective inhibition of mushroom tyrosinase in vitro with a Ki that is 10-fold lower that hydroquinone (HQ) and 350-fold lower than arbutin. [1] DeoxyArbutin exhibits toxicity in darkly (higher tyrosinase activity) and lightly (lower tyrosinase activity) pigmented melanocytes with IC50 of 57.5 μM and 104.7 μM. DeoxyArbutin (100 μM) dose-dependently inhibits tyrosine hydroxylase activity in lysate from untreated, darkly pigmented melanocytes. DeoxyArbutin (100 μM) inhibits tyrosine hydroxylase activity of mushroom tyrosinase in a dose-dependent manner. DeoxyArbutin inhibits tyrosine hydroxylase activity of mushroom tyrosinase with IC50 of 17.5 μM and Ki of 21.6 μM. [2] Water increases the decomposition of DeoxyArbutin in the formulations and the polyol-in-silicone, oil-based, anhydrous emulsion system provides a relatively stable surrounding for the DeoxyArbutin that delays its degradation at 25 ℃ and 45 ℃. [3] DeoxyArbutin inhibits melanin synthesis in intact melanocytes in a dose-dependent manner. DeoxyArbutin exhibits dose-dependent reductions in melanocyte cell number, primarily due to inhibition of proliferation rather than initiation of apoptosis. DeoxyArbutin increases minimal amounts of reactive oxygen species (ROS) with subsequently induced expression of the endogenous antioxidant catalase in treated melanocytes.[4]
In vivo

DeoxyArbutin (3%) demonstrates rapid and sustained skin lightening that is completely reversible within 8 weeks after halt in topical application in a hairless, pigmented guinea pig model. [1]
References

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.