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Deoxyarbutin Tyrosinase inhibitor

Cat.No.S4132

DeoxyArbutin(D-arbutin,D-Arb) is a reversible tyrosinase inhibitor, inhibiting tyrosinase activity with IC50 of 50 nM.
Deoxyarbutin Tyrosinase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 194.23

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Quality Control

Batch: S413201 DMSO]39 mg/mL]false]Ethanol]39 mg/mL]false]Water]Insoluble]false Purity: 99.32%
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99.32

Solubility

In vitro
Batch:

DMSO : 39 mg/mL (200.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 39 mg/mL

Water : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 194.23 Formula

C11H14O3

 Storage (From the date of receipt)
CAS No. 53936-56-4 Download SDF Storage of Stock Solutions

Synonyms D-arbutin,D-Arb Smiles C1CCOC(C1)OC2=CC=C(C=C2)O

Mechanism of Action

Features
More effective than hydroquinone in inhibiting mushroom tyrosinase.
Targets/IC50/Ki
tyrosinase
50 nM
In vitro

DeoxyArbutin demonstrates effective inhibition of mushroom tyrosinase in vitro with a Ki that is 10-fold lower that hydroquinone (HQ) and 350-fold lower than arbutin. DeoxyArbutin exhibits toxicity in darkly (higher tyrosinase activity) and lightly (lower tyrosinase activity) pigmented melanocytes with IC50 of 57.5 μM and 104.7 μM. DeoxyArbutin (100 μM) dose-dependently inhibits tyrosine hydroxylase activity in lysate from untreated, darkly pigmented melanocytes. DeoxyArbutin (100 μM) inhibits tyrosine hydroxylase activity of mushroom tyrosinase in a dose-dependent manner. DeoxyArbutin inhibits tyrosine hydroxylase activity of mushroom tyrosinase with IC50 of 17.5 μM and Ki of 21.6 μM. Water increases the decomposition of DeoxyArbutin in the formulations and the polyol-in-silicone, oil-based, anhydrous emulsion system provides a relatively stable surrounding for the DeoxyArbutin that delays its degradation at 25 ℃ and 45 ℃. DeoxyArbutin inhibits melanin synthesis in intact melanocytes in a dose-dependent manner. DeoxyArbutin exhibits dose-dependent reductions in melanocyte cell number, primarily due to inhibition of proliferation rather than initiation of apoptosis. DeoxyArbutin increases minimal amounts of reactive oxygen species (ROS) with subsequently induced expression of the endogenous antioxidant catalase in treated melanocytes.
In vivo

DeoxyArbutin (3%) demonstrates rapid and sustained skin lightening that is completely reversible within 8 weeks after halt in topical application in a hairless, pigmented guinea pig model.

References
  • [4] https://pubmed.ncbi.nlm.nih.gov/23134995/

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