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2-Hydroxyisocaproic acid

Cat.No.E0652

2-hydroxyisocaproic acid (HICA), an amino acid derivative, has broad antibacterial activity.
2-Hydroxyisocaproic acid Chemical Structure

Chemical Structure

Molecular Weight: 132.16

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: E065201 DMSO]26 mg/mL]false]Water]26 mg/mL]false]Ethanol]26 mg/mL]false Purity: 99%
99

Chemical Information, Storage & Stability

Molecular Weight 132.16 Formula

C6H12O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 498-36-2 -- Storage of Stock Solutions

Synonyms HICA Smiles CC(C)CC(O)C(O)=O

Solubility

In vitro
Batch:

DMSO : 26 mg/mL ( (196.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 26 mg/mL

Ethanol : 26 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vitro

2-Hydroxyisocaproic acid is not cytotoxic and genotoxic at concentrations <10 mg/mL. At the concentration of 1 mg/mL, this compound is significantly less cytotoxic than calcium hydroxide.[2]
In vivo

2-Hydroxyisocaproic acid reduces expression of matrix metalloproteinase 9 (MMP-9) and myeloperoxidase (MPO) in a murine chamber model of C. albicans biofilm, compared to those of chambers containing caspofungin and PBS.[3]
References

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