Home Microbiology Parasite inhibitor Tinidazole For research use only.

Tinidazole

Synonyms: CP12574

Tinidazole (CP12574) is an anti-parasitic drug.

Tinidazole Chemical Structure

Tinidazole Chemical Structure

CAS: 19387-91-8

Selleck's Tinidazole has been cited by 1 publication

Purity & Quality Control

Batch: S406801 DMSO] 49 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.94%
99.94

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Biological Activity

Description Tinidazole (CP12574) is an anti-parasitic drug.
In vitro
In vitro Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. [1] Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. [2] Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. [3] Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. [4] Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05383521 Not yet recruiting
Trichomonas Vaginitis
Shangrong Fan|Peking University Shenzhen Hospital
 December 1 2023 Not Applicable
NCT00324142 Withdrawn
Recurrent Bacterial Vaginosis
Kaiser Permanente
 Phase 2

Chemical Information & Solubility

Molecular Weight 247.27 Formula

C8H13N3O4S
CAS No. 19387-91-8 SDF Download Tinidazole SDF
Smiles CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (198.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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