Notch Activators

Cat.No.	Product Name	Information	Product Use Citations
E6836^New	Yhhu-3792 hydrochloride	Yhhu-3792 hydrochloride is a Notch activator that enhances the self-renewal capability of neural stem cells (NSCs) and promotes the expression of Hes3 and Hes5. It increases the spatial and episodic memory abilities of mice by expanding the NSC pool and promoting endogenous neurogenesis in the hippocampal dentate gyrus. It exhibits potential to be used in the study of neurodegenerative diseases such as Alzheimer's disease, or for neural regeneration after brain injury.
S3944	VPA (Valproic acid)	Valproic acid (VPA) is a fatty acid with anticonvulsant properties used in the treatment of epilepsy. It is also a histone deacetylase (HDAC) inhibitor and is under investigation for treatment of HIV and various cancers. This compound induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α. Additionally, it activates Notch-1 signaling.	Genome Biology, 2026, 73 Genome Biol, 2026, 27(1)73 Cell, 2025, S0092-8674(25)00406-4
S1168	Sodium Valproate (Valproic acid sodium)	Valproic Acid sodium is a HDAC inhibitor by selectively inducing proteasomal degradation of HDAC2, used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic acid induces Notch1 signaling in small cell lung cancer (SCLC) cells. Valproic acid is under investigation for treatment of HIV and various cancers. Valproic acid (VPA) induces autophagy and mitophagy by upregulation of BNIP3 and mitochondrial biogenesis by upregulating PGC-1α.	J Exp Clin Cancer Res, 2024, 43(1):152 J Immunother Cancer, 2024, 12(11)e009805 Front Pharmacol, 2024, 15:1534772
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