LSD1 Inhibitors

Featured Inhibitors
Inhibitors (12)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7795	Ladademstat (ORY-1001) Dihydrochloride	ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.	EMBO Rep, 2025, 10.1038/s44319-025-00385-w Nat Commun, 2024, 15(1):5631 Cell Death Discov, 2024, 10(1):166
S7237	OG-L002	OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.	Cancer Res Commun, 2025, 5(9):1584-1598 bioRxiv, 2025, 2025.06.20.660795 Cell Death Discov, 2024, 10(1):166

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7795

Ladademstat (ORY-1001) Dihydrochloride

ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.

EMBO Rep, 2025, 10.1038/s44319-025-00385-w

Nat Commun, 2024, 15(1):5631

Cell Death Discov, 2024, 10(1):166

Verified customer review of Ladademstat (ORY-1001) Dihydrochloride

S7237

OG-L002

OG-L002 is a potent and specific LSD1 inhibitor with IC50 of 20 nM in a cell-free assay, exhibiting 36- and 69-fold selectivity over MAO-B and MAO-A, respectively.

Cancer Res Commun, 2025, 5(9):1584-1598

bioRxiv, 2025, 2025.06.20.660795

Cell Death Discov, 2024, 10(1):166