• RORα
  • RORγ

RORgamma Selective Inhibitors | Agonists

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S8860 Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ. Selective
S6610 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ. Selective
S3483 TMP778 TMP778 is a selective inhibitor of RORγt with an IC50 of 5 nM in the Fluorescence Resonance Energy Transfer (FRET) assay and an IC50 of 17 nM in the RORγ assay. Selective RORγt, IC50: 5 nM; RORγt, IC50: 17 nM
S0094 SR 0987 SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. SR 0987 represses PD-1, produces IL17 and is potential for the treatment of cancer. Selective RORγt, EC50: 800 nM
S6724 SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively. Pan RORγ, Ki: 111 nM
S5775 SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist. Pan