ROR Agonists

Cat.No.	Product Name	Information	Product Use Citations
S5775	SR1078	SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist.	FEBS J, 2022, 289(21):6643-6658 Cell Death Dis, 2021, 12(3):247
S6610	GSK2981278	GSK2981278 is a highly potent and selective inverse agonist for RORγ.	bioRxiv, 2022, 10.1101/2022.11.30.518024
S8860	Cintirorgon (LYC-55716)	Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ.
E0637	Cedirogant	Cedirogant (ABBV-157) is an orally active RORγt inverse agonist, can be used for psoriasis research.
S6724	SR1001	SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively.
S2654	Neoruscogenin	Neoruscogenin, a natural sapogenin isolated from R. rhizoma, is a potent and high-affinity agonist of RAR-related orphan receptor alpha (RORα or nuclear receptor NR1F1).
S2969	SR3335	SR3335 (ML-176) is a selective and inverse agonist of retinoic acid receptor-related receptor α (RORα) that directly binds to RORα with Ki of 220 nM.
S7076	T0901317	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of 20nM for LXRα and 5 μM for FXR, respectively. This compound is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. It significantly suppresses cell proliferation and induces apoptosis.	J Clin Invest, 2025, 135(10)e186478 J Exp Med, 2025, 222(3)e20230647 Neurobiol Dis, 2025, 215:107094
S0094	SR 0987	SR 0987, a SR 1078 analog, is an agonist for T cell-specific RORγ (RORγt) with EC50 of 800 nM. This compound represses PD-1, produces IL17 and is potential for the treatment of cancer.	Evid Based Complement Alternat Med, 2022, 2022:8315503.