Home Endocrinology & Hormones RAAS inhibitor - ACE inhibitor Trandolapril For research use only.

Trandolapril

Synonyms: RU44570

Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.

Trandolapril Chemical Structure

Trandolapril Chemical Structure

CAS: 87679-37-6

Purity & Quality Control

Batch: S646801 DMSO] 86 mg/mL] false] Ethanol] 43 mg/mL] false] Water] Insoluble] false Purity: 99.8%
99.8

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Signaling Pathway

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Biological Activity

Description Trandolapril(RU44570) is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00887510 Completed
Hypertension
University of Florida|National Heart Lung and Blood Institute (NHLBI)
 May 2007 Phase 4
NCT00840073 Completed
Healthy
Teva Pharmaceuticals USA
 October 2004 Phase 1
NCT00840632 Completed
Healthy
Teva Pharmaceuticals USA
 October 2004 Phase 1
NCT00233532 Completed
Hypertension
Abbott
 March 2004 Phase 4

Chemical Information & Solubility

Molecular Weight 430.54 Formula

C24H34N2O5
CAS No. 87679-37-6 SDF --
Smiles CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 86 mg/mL ( (199.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 43 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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