- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S2196||Dabigatran (BIBR 953)||<1 mg/mL||0.5 mg/mL||0.01 mg/mL|
|S2229||Eltrombopag Olamine||<1 mg/mL||89 mg/mL||<1 mg/mL|
|S2154||Dabigatran Etexilate||<1 mg/mL||126 mg/mL||12 mg/mL|
|S1346||Heparin sodium||100 mg/mL||<1 mg/mL||<1 mg/mL|
|S2069||Argatroban||<1 mg/mL||9 mg/mL||6 mg/mL|
|S3200||Triflusal||<1 mg/mL||50 mg/mL||50 mg/mL|
|S4740||Sodium ferulate||43 mg/mL||2 mg/mL||<1 mg/mL|
|S4276||Etizolam||<1 mg/mL||26 mg/mL||62 mg/mL|
|S4502||Eltrombopag||<1 mg/mL||26 mg/mL||<1 mg/mL|
|S2369||Troxerutin||100 mg/mL||100 mg/mL||<1 mg/mL|
- Thrombin Inhibitors (11)
|Catalog No.||Information||Product Use Citations||Product Validations|
Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.
The peak fluorescence of each time course at the specified drug concentration are plotted as a function of concentration of (C) dabigatran. Each dose-response curve was fitted to the Hill equation, and these curves are shown in red for thrombin inhibitors (B,C).
Eltrombopag Olamine is a member of the biarylhydrazone class, which is a nonpeptide agonist of the thrombopoietin receptor (TpoR).
Dabigatran Etexilate is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.
Heparin sodium, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has numerous important biological activities associated with its interaction with diverse proteins, used as an anticoagulant.
Argatroban is a potent and selective synthetic thrombin inhibitor with Ki ranging from 5 nM to 39 nM, used as an anticoagulant.
Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.
Warfarin is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.
Sodium ferulate (SF), the sodium salt of ferulic acid, is a drug used in traditional Chinese medicine for treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.
Etizolam is a specific platelet-activating factor (PAF) antagonist with anti-anxiety activity.
Eltrombopag, a member of the biarylhydrazone class, is a nonpeptide agonist of the thrombopoietin receptor (TpoR), used to treat chronic hepatitis C-associated thrombocytopenia and chronic immune (idiopathic) thrombocytopenia (ITP).
Effect of eltrombopag on cell cycle progression in Huh7 cells. (A) Cells were treated with EP (0 and 10 μg/ml) for 72 h. DNA was stained with propidium iodide, and flow cytometric analysis of cell phase distribution was performed using a Muse™ cell analyzer. (B) Cells were treated with EP (0, 1 and 10 μg/ml) for 72 h. Protein expression was determined by western blot analysis using anti-cyclin D1, anti-p21 and anti-GAPDH antibodies. SDS-PAGE was performed on acrylamide gels.
Troxerutin, a natural bioflavonoid isolated from Sophora japonica., has been reported to have many benefits and medicinal properties.