Home Protein Tyrosine Kinase VEGFR inhibitor - PDGFR inhibitor Vorolanib For research use only.

Vorolanib

Synonyms: X-82,CM082

Vorolanib (X-82,CM082) is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.

Vorolanib Chemical Structure

Vorolanib Chemical Structure

CAS: 1013920-15-4

Purity & Quality Control

Batch: S684301 DMSO] 89 mg/mL] false] Ethanol] 5 mg/mL] false] Water] ˂1 mg/mL] false Purity: 99.83%
99.83

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Signaling Pathway

VEGFR Signaling Pathways

VEGFR Signaling Pathway

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Biological Activity

Description Vorolanib (X-82,CM082) is an oral, multikinase, dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with antiangiogenic and antineoplastic activities.
Targets
VEGFR [1] PDGFR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04126668 Completed
Advanced Malignant Solid Tumors
AnewPharma
 December 19 2019 Phase 1
NCT03511222 Terminated
Solid Tumor|Hepatocellular Carcinoma|Gastric Cancer|Gastroesophageal Junction Adenocarcinoma
Washington University School of Medicine|Xcovery Holding Company LLC
 September 11 2018 Phase 1
NCT02577458 Unknown status
Renal Cell Carcinoma Recurrent
AnewPharma|Peking University Cancer Hospital & Institute
 September 2015 Phase 1
NCT02452385 Suspended
Age-Related Macular Degeneration
AnewPharma|West China Hospital
 March 2015 Phase 1

Chemical Information & Solubility

Molecular Weight 439.4 Formula

C23H26FN5O3
CAS No. 1013920-15-4 SDF --
Smiles CC1=C(NC(=C1C(=O)NC2CCN(C2)C(=O)N(C)C)C)C=C3C4=C(C=CC(=C4)F)NC3=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 89 mg/mL ( (202.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : ˂1 mg/mL


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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