Home Transmembrane Transporters Potassium Channel inhibitor Tetraethylammonium chloride For research use only.

Tetraethylammonium chloride

Synonyms: TEA chloride

Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.

Tetraethylammonium chloride Chemical Structure

Tetraethylammonium chloride Chemical Structure

CAS: 56-34-8

Purity & Quality Control

Batch: S448901 DMSO] 33 mg/mL] false] Water] 33 mg/mL] false] Ethanol] 33 mg/mL] false Purity: 98.06%
98.06

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Signaling Pathway

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Potassium Channel Signaling Pathway

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Biological Activity

Description Tetraethylammonium (TEA) chloride is a nonspecific potassium channel blocker with antitumor properties.
Targets
Potassium channel [1]
In vitro
In vitro

5 mmol/L Tetraethylammonium indeed modestly augments the [Ca2+]i response to PK‐THPP and also alters the response to A1899 (in so far as peak [Ca2+]i is increased but not mean [Ca2+]i).[2]
Cell Research Cell lines native glomus cells and HEK293 cells
Concentrations 5 mM
Incubation Time --
Method

Cell‐attached patch clamp recordings were performed on glomus cells, or HEK 293 cells (transfected with TASK1 or TASK3), using an Axopatch 200B. Borosilicate pipettes were sylgard‐coated, fire‐polished and filled with a solution containing (in mM) 140 KCl, 1 MgCl2, 1 EGTA, 10 HEPES, 10 tetraethylammonium (TEA), and 5 4‐aminopyridine. The pH of this solution was adjusted to 7.4 at 37°C using KOH.

Chemical Information & Solubility

Molecular Weight 165.7 Formula
C8H20ClN
CAS No. 56-34-8 SDF --
Smiles [Cl-].CC[N+](CC)(CC)CC
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 33 mg/mL ( (199.15 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 33 mg/mL

Ethanol : 33 mg/mL


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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