Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

Size Price Stock Quantity  
In DMSO USD 280 In stock
USD 147 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

3 Customer Reviews

  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell NWDQd4dCT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmntTY5pcWKrdHnvckBw\iCqdX3hckBNWC1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Mz6zO|EyOiEQvF2= NIG1cIpUSU6JRWK=
human 697 cell NF76NHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH7VU4VKdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPVg4QDhizszN NVTUdYRuW0GQR1XS
human ALL-PO cell M4K5U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4LZXmlvcGmkaYTpc44hd2ZiaIXtZY4hSUyOLWDPJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE4xQDZ3NTFOwG0> NHXGcZdUSU6JRWK=
human ML-2 cell NEn5Oo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXj6SFUzUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE43OTh|MzFOwG0> NVm4[I5uW0GQR1XS
human LB2241-RCC cell Mn3qS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFrGUodKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Lkm4OVczKM7:TR?= M3XEV3NCVkeHUh?=
human Becker cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MY\Jcohq[mm2aX;uJI9nKGi3bXHuJGJm[2uncjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWuO|k1ODFizszN MkHOV2FPT0WU
human NEC8 cell NWHtTYM3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlvuTY5pcWKrdHnvckBw\iCqdX3hckBPTUN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6wOVM{OSEQvF2= NWeySpJoW0GQR1XS
human Daudi cell NIPvSWhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnjkTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uN|M3QTlizszN NYTC[ot3W0GQR1XS
human MHH-PREB-1 cell NFvJUGNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkLwTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi55OEixO{DPxE1? NXXNdoFNW0GQR1XS
human NCI-H510A cell NX;3S286T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Mlf2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB|NUO1JO69VQ>? MoTpV2FPT0WU
human NCI-H720 cell NIq1d3FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NELxUIVKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IO|IxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py53N{K2PEDPxE1? M3W0eHNCVkeHUh?=
human MRK-nu-1 cell M2rlPGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3zCXGlvcGmkaYTpc44hd2ZiaIXtZY4hVVKNLX71MVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njd3MUexJO69VQ>? NGHvNW9USU6JRWK=
human LB2518-MEL cell NGr0dZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njl5M{K2JO69VQ>? NIjNcXJUSU6JRWK=
human BE-13 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX7Jcohq[mm2aX;uJI9nKGi3bXHuJGJGNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD6yOlg1KM7:TR?= NX30doZKW0GQR1XS
human A3-KAW cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4T3WGlvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE41OzJ6OTFOwG0> Mn\IV2FPT0WU
human ST486 cell NELUZYZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUHJcohq[mm2aX;uJI9nKGi3bXHuJHNVPDh4IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD61N|Y5KM7:TR?= MoDtV2FPT0WU
human ES8 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MofLTY5pcWKrdHnvckBw\iCqdX3hckBGWzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16Lk[0N|M6KM7:TR?= NInncmRUSU6JRWK=
human HT cell NWTXPIZJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFrZclBKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD65OFE5PSEQvF2= NU\hRYRCW0GQR1XS
human HAL-01 cell MoDpS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlPRTY5pcWKrdHnvckBw\iCqdX3hckBJSUxvMEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlMyPTB3IN88US=> NF\vXmFUSU6JRWK=
human EB-3 cell MVHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXrJcohq[mm2aX;uJI9nKGi3bXHuJGVDNTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17Lk[yOVczKM7:TR?= NWToVpc3W0GQR1XS
human EW-1 cell NVrTdFA4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NV76bI9rUW6qaXLpeIlwdiCxZjDoeY1idiCHVz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU44OTJ2IN88US=> M3q2enNCVkeHUh?=
human BL-41 cell NHnZVVVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVTJcohq[mm2aX;uJI9nKGi3bXHuJGJNNTRzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT63PFA1QSEQvF2= NWK5ephQW0GQR1XS
Ramos-2G6-4C10 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{KyemlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlkxOzF3IN88US=> NXTlTVRFW0GQR1XS
human DOHH-2 cell NE\3fIhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVnJcohq[mm2aX;uJI9nKGi3bXHuJGRQUEhvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlIzPjJizszN M{fqd3NCVkeHUh?=
MONO-MAC-6 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2m1fGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:QTz3NRWMuPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkW0PFMh|ryP NYrBbYpWW0GQR1XS
human NKM-1 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnKwTY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlYyQTZizszN MX7TRW5ITVJ?
human HEL cell MorvS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3u4UGlvcGmkaYTpc44hd2ZiaIXtZY4hUEWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOlI2OiEQvF2= MXfTRW5ITVJ?
human 8-MG-BA cell M4q4R2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnfVTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQTl7OTFOwG0> NVnKTplsW0GQR1XS
human K-562 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnjTTY5pcWKrdHnvckBw\iCqdX3hckBMNTV4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlAyQTFizszN MorlV2FPT0WU
human LXF-289 cell MmfIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7ST41QUW6qaXLpeIlwdiCxZjDoeY1idiCOWF[tNlg6KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwMUW0O{DPxE1? M3LydnNCVkeHUh?=
human HC-1 cell M1;rRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{H4O2lvcGmkaYTpc44hd2ZiaIXtZY4hUENvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlE2PDdizszN MnyyV2FPT0WU
human MC116 cell NU\4cnc3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmfITY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlIxPzNizszN MWXTRW5ITVJ?
human TE-12 cell M{CxeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXvJcohq[mm2aX;uJI9nKGi3bXHuJHRGNTF{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuN|M2PyEQvF2= M13CfHNCVkeHUh?=
human BV-173 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2LHWGlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPTB{MTFOwG0> NILBNZlUSU6JRWK=
human NCCIT cell MnvBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7FTlNkUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjZyM{mg{txO NFnxZZVUSU6JRWK=
human CESS cell NFLWVXhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVjGPVlLUW6qaXLpeIlwdiCxZjDoeY1idiCFRWPTJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjZ4MjFOwG0> NGPDO|lUSU6JRWK=
human HUTU-80 cell Mn:5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{TCbmlvcGmkaYTpc44hd2ZiaIXtZY4hUFWWVT24NEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjZ5MESg{txO NWi2UYlFW0GQR1XS
human IST-SL2 cell NEGybIZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M2LhXWlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd5MESg{txO NFzaW3lUSU6JRWK=
human ATN-1 cell M1TpTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfFSHhKdmirYnn0bY9vKG:oIHj1cYFvKEGWTj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvODJ{NjFOwG0> M1y2N3NCVkeHUh?=
human HCC1599 cell MoTKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIjXXW9KdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{G1PVkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi5zMEm0JO69VQ>? MmTRV2FPT0WU
human NTERA-S-cl-D1 cell M1fQXmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUDJcohq[mm2aX;uJI9nKGi3bXHuJG5VTVKDLWOtZ4wuTDFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMj64PFg5KM7:TR?= NGrZNI1USU6JRWK=
human EVSA-T cell MWTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4jwOmlvcGmkaYTpc44hd2ZiaIXtZY4hTV[VQT3UJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvQTJyNDFOwG0> NXu2SHhYW0GQR1XS
human NALM-6 cell NX\KVHFQT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoLkTY5pcWKrdHnvckBw\iCqdX3hckBPSUyPLU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU4hUUN3ME2xN{4xQTJ7IN88US=> NYfNNlR6W0GQR1XS
human KMOE-2 cell M1TlWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{OxOWlvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvOTB7MjFOwG0> MWHTRW5ITVJ?
human HL-60 cell NEnhW|NIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWnJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuN|MxQCEQvF2= MYTTRW5ITVJ?
human D-542MG cell NWj2T2R{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTR{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{41OzB4IN88US=> M{DI[HNCVkeHUh?=
human L-363 cell M33JSWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWXJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOVU5OyEQvF2= MnrRV2FPT0WU
human CMK cell NUD0dmF5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{C4emlvcGmkaYTpc44hd2ZiaIXtZY4hS02NIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuO|Q{PiEQvF2= NV[xNm83W0GQR1XS
human IMR-5 cell M1fLW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NV3NNXY3UW6qaXLpeIlwdiCxZjDoeY1idiCLTWKtOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njd6NEmg{txO NX;NO29sW0GQR1XS
human A101D cell MmnOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIHrVYhKdmirYnn0bY9vKG:oIHj1cYFvKEFzMEHEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQDJyNzFOwG0> M3T0cnNCVkeHUh?=
human MOLT-16 cell NH7Ubo1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH;TS5RKdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57Nk[1JO69VQ>? MV7TRW5ITVJ?
human LU-139 cell NGezTYdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXjFcJp[UW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC5yNES0JO69VQ>? MYTTRW5ITVJ?
human OVCAR-4 cell M1z6OGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MnPjTY5pcWKrdHnvckBw\iCqdX3hckBQXkODUj20JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPzZyNDFOwG0> MYTTRW5ITVJ?
human BC-3 cell NVXrOph4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MWLJcohq[mm2aX;uJI9nKGi3bXHuJGJENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND63PVgzKM7:TR?= NVr0S2F4W0GQR1XS
PC12 cells NX7td2loTnWwY4Tpc44h[XO|YYm= NU\ZTYVyS3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgc44hemG2IIT1colk[W27Y3nuJJRz\WG2ZXSgdoF1KHCqZX;jbJJwdW:leYTvcYEh[2WubDDsbY5mKFCFMUKg[pJwdSCjcH;weI9{cXNiaX7keYNm\CCkeTDFcoRweGyjc33pZ{Bz\XSrY4XseY0he3S{ZYPzMEBGSzVyPUG1JO69VQ>? NFywR|AyPjByMkK4PC=>
human D-336MG cell Mmf1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmrqTY5pcWKrdHnvckBw\iCqdX3hckBFNTN|Nl3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVUvOTF|NDFOwG0> NHH4cGdUSU6JRWK=
human BC-1 cell MlPUS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIjhe2xKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yQThizszN M2rlcXNCVkeHUh?=
human KE-37 cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2ezXmlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4zQDJ2IN88US=> NHTLbGVUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Antibodies

Tags: buy Salubrinal | Salubrinal supplier | purchase Salubrinal | Salubrinal cost | Salubrinal manufacturer | order Salubrinal | Salubrinal distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID