Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
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  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell MmTIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2LpVGlvcGmkaYTpc44hd2ZiaIXtZY4hVFBvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuN|cyOTJizszN NVfhSGNHW0GQR1XS
human 697 cell MnTGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJFY6PyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTNwOUi3PFgh|ryP NXr0[IpQW0GQR1XS
human ALL-PO cell M1jVR2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmfVTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlA5PjV3IN88US=> MXHTRW5ITVJ?
human ML-2 cell NVfoO2w5T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MofiTY5pcWKrdHnvckBw\iCqdX3hckBOVC1{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;ND62NVg{OyEQvF2= MX3TRW5ITVJ?
human LB2241-RCC cell NHH6WZlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Ml3UTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC57OEW3NkDPxE1? M{XSO3NCVkeHUh?=
human Becker cell MV7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NInzeoxKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzl2MEGg{txO MWTTRW5ITVJ?
human NEC8 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEXXWo1KdmirYnn0bY9vKG:oIHj1cYFvKE6HQ{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME22MlA2OzNzIN88US=> NIXQV5VUSU6JRWK=
human Daudi cell M{K2SWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHezWJdKdmirYnn0bY9vKG:oIHj1cYFvKESjdXTpJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9Ok4{OzZ7OTFOwG0> M{T0THNCVkeHUh?=
human MHH-PREB-1 cell MXTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkjaTY5pcWKrdHnvckBw\iCqdX3hckBOUEhvUGLFRk0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Pi55OEixO{DPxE1? NU\5eI9xW0GQR1XS
human NCI-H510A cell NHnPfVBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkDLTY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEWxNGEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjB|NUO1JO69VQ>? MX7TRW5ITVJ?
human NCI-H720 cell NVP5[2U1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkL2TY5pcWKrdHnvckBw\iCqdX3hckBPS0lvSEeyNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVcvPTd{Nkig{txO NVP5dXMzW0GQR1XS
human MRK-nu-1 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFPLRVJKdmirYnn0bY9vKG:oIHj1cYFvKE2USz3ueU0yKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py55NUG3NUDPxE1? M2jlRnNCVkeHUh?=
human LB2518-MEL cell NIK4b4pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXfUUo5IUW6qaXLpeIlwdiCxZjDoeY1idiCOQkK1NVguVUWOIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nz65O|MzPiEQvF2= NHHWSmlUSU6JRWK=
human BE-13 cell NHnXOVVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mm\mTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNlY5PCEQvF2= MWHTRW5ITVJ?
human A3-KAW cell Ml[4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M2TVS2lvcGmkaYTpc44hd2ZiaIXtZY4hSTNvS1HXJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE41OzJ6OTFOwG0> NHfrfXRUSU6JRWK=
human ST486 cell MmrGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX7DZndZUW6qaXLpeIlwdiCxZjDoeY1idiCVVES4OkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPTN4ODFOwG0> NV7mW2MyW0GQR1XS
human ES8 cell M2T0fWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NYjmVYFHUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlY1OzN7IN88US=> Ml;YV2FPT0WU
human HT cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NIS0XYZKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD65OFE5PSEQvF2= M3na[3NCVkeHUh?=
human HAL-01 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2S3bWlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4{OTVyNTFOwG0> NHrlbldUSU6JRWK=
human EB-3 cell NGXUcVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3jvdGlvcGmkaYTpc44hd2ZiaIXtZY4hTUJvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuOlI2PzJizszN NFnzcWJUSU6JRWK=
human EW-1 cell Mn;HS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF7xd2tKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlcyOjRizszN M2LEU3NCVkeHUh?=
human BL-41 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkfzTY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuO|gxPDlizszN NYP1S2gzW0GQR1XS
Ramos-2G6-4C10 cell NWDNXnJST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXrJPWQ{UW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvQTB|MUWg{txO NVLu[5lKW0GQR1XS
human DOHH-2 cell MX3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{PMb2lvcGmkaYTpc44hd2ZiaIXtZY4hTE:KSD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvOjJ4MjFOwG0> M1;yXHNCVkeHUh?=
MONO-MAC-6 cell NInUfHZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWXJcohq[mm2aX;uJI9nKGi3bXHuJG1QVk9vTVHDMVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC53NEizJO69VQ>? MkGzV2FPT0WU
human NKM-1 cell NHXSV5ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlG0TY5pcWKrdHnvckBw\iCqdX3hckBPU01vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlYyQTZizszN MUjTRW5ITVJ?
human HEL cell MmDGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NY[4NWNMUW6qaXLpeIlwdiCxZjDoeY1idiCKRVygZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43OjV{IN88US=> NILvWWNUSU6JRWK=
human 8-MG-BA cell MnmwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXTGTWZwUW6qaXLpeIlwdiCxZjDoeY1idiB6LV3HMWJCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwOUm5PUDPxE1? NVvS[mVZW0GQR1XS
human K-562 cell MkDxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJGsuPTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuNFE6OSEQvF2= M{\zbXNCVkeHUh?=
human LXF-289 cell MYLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXLJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4yPTR5IN88US=> M{jhWXNCVkeHUh?=
human HC-1 cell NHPTboVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlrVTY5pcWKrdHnvckBw\iCqdX3hckBJSy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuNVU1PyEQvF2= MXvTRW5ITVJ?
human MC116 cell M3zmb2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEn5e4lKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOjB5MzFOwG0> MmK5V2FPT0WU
human TE-12 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHrQU4VKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOzN3NzFOwG0> NG\wNGZUSU6JRWK=
human BV-173 cell NFHaXY1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1jK[WlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPTB{MTFOwG0> MoH1V2FPT0WU
human NCCIT cell Mn2zS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M325TWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOFSWSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU43ODN7IN88US=> MXTTRW5ITVJ?
human CESS cell MoX1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYXJcohq[mm2aX;uJI9nKGi3bXHuJGNGW1NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMT62OlYzKM7:TR?= M4TGdHNCVkeHUh?=
human HUTU-80 cell NVOzWpU6T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWrXV3U3UW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNkewOEDPxE1? MmP6V2FPT0WU
human IST-SL2 cell MnfTS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M1L1cGlvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd5MESg{txO M{GzfXNCVkeHUh?=
human ATN-1 cell MkXkS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrWTY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlAzOjZizszN NHnI[WJUSU6JRWK=
human HCC1599 cell NGfaSlZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3L3S2lvcGmkaYTpc44hd2ZiaIXtZY4hUEOFMUW5PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEzNjFyOUSg{txO NXTyZ2gyW0GQR1XS
human NTERA-S-cl-D1 cell NVLFV4p1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NX\jNodyUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvQDh6ODFOwG0> MWjTRW5ITVJ?
human EVSA-T cell NFjuRlFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MkH6TY5pcWKrdHnvckBw\iCqdX3hckBGXlODLWSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk46OjB2IN88US=> MY\TRW5ITVJ?
human NALM-6 cell NWPLUmJnT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJG5CVE1vNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MkBKSzVyPUGzMlA6OjlizszN MXHTRW5ITVJ?
human KMOE-2 cell MW\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVjJcohq[mm2aX;uJI9nKGi3bXHuJGtOV0VvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlExQTJizszN NXuwXJY1W0GQR1XS
human HL-60 cell NYn4bnFsT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4rEVWlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4{OzB6IN88US=> M2TQVXNCVkeHUh?=
human D-542MG cell M1nSbWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWjJcohq[mm2aX;uJI9nKGi3bXHuJGQuPTR{TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{41OzB4IN88US=> NUTZW4pkW0GQR1XS
human L-363 cell MmS5S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYT4OlA4UW6qaXLpeIlwdiCxZjDoeY1idiCOLUO2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjV3OEOg{txO Mn3YV2FPT0WU
human CMK cell MnO2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlfvTY5pcWKrdHnvckBw\iCqdX3hckBEVUtiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMz63OFM3KM7:TR?= MljvV2FPT0WU
human IMR-5 cell NFiyemtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnHQTY5pcWKrdHnvckBw\iCqdX3hckBKVVJvNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlc5PDlizszN NETYZ2lUSU6JRWK=
human A101D cell Ml74S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmPhTY5pcWKrdHnvckBw\iCqdX3hckBCOTBzRDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlgzODdizszN MWTTRW5ITVJ?
human MOLT-16 cell MnntS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{m1cGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:OVD2xOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njl4NkWg{txO NUn1OJMxW0GQR1XS
human LU-139 cell M1rNeGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJGxWNTF|OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlA1PDRizszN MV\TRW5ITVJ?
human OVCAR-4 cell MoXtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVvJcohq[mm2aX;uJI9nKGi3bXHuJG9XS0GULUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE44PjB2IN88US=> NF3qUJRUSU6JRWK=
human BC-3 cell NWjGXJpWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MXvJcohq[mm2aX;uJI9nKGi3bXHuJGJENTNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zND63PVgzKM7:TR?= MnO2V2FPT0WU
PC12 cells NFLVfmxHfW6ldHnvckBie3OjeR?= MXHDfZRweHKxdHXjeIl3\SCjY4Tpeol1gSCxbjDyZZQhfHWwaXPhcZlkcW5idILlZZRm\CC{YYSgdIhmd2Oqcn;tc4N6fG:vYTDj[YxtKGyrbnWgVGMyOiCocn;tJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KEWwZH;wcIF{dWmlIILleIlkfWy3bTDzeJJme3NuIFXDOVA:OTVizszN NVrTVndZOTZyMEKyPFg>
human D-336MG cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVPTTot[UW6qaXLpeIlwdiCxZjDoeY1idiCGLUOzOm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTVwMUGzOEDPxE1? MV\TRW5ITVJ?
human BC-1 cell NH7p[5hIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEHrNHZKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yQThizszN NESybWdUSU6JRWK=
human KE-37 cell MmP2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3\IcmlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4zQDJ2IN88US=> NF7Gc2RUSU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID