Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
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  • J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell M1vJTGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MYHJcohq[mm2aX;uJI9nKGi3bXHuJGxRNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkO3NVEzKM7:TR?= MljNV2FPT0WU
human 697 cell M3O1fmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NX3pW3EzUW6qaXLpeIlwdiCxZjDoeY1idiB4OUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlk5Pzh6IN88US=> NInRPZRUSU6JRWK=
human ALL-PO cell NFnhTmNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoLaTY5pcWKrdHnvckBw\iCqdX3hckBCVExvUF:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlA5PjV3IN88US=> NV;IRoM6W0GQR1XS
human ML-2 cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVfWdVliUW6qaXLpeIlwdiCxZjDoeY1idiCPTD2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OE43OTh|MzFOwG0> MnzIV2FPT0WU
human LB2241-RCC cell MUfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoPVTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ{NEGtVmNEKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PC57OEW3NkDPxE1? M17IPHNCVkeHUh?=
human Becker cell M2q3N2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH\Wd4RKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzl2MEGg{txO M{P6TnNCVkeHUh?=
human NEC8 cell NFHSe|JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MojZTY5pcWKrdHnvckBw\iCqdX3hckBPTUN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6wOVM{OSEQvF2= MWLTRW5ITVJ?
human Daudi cell NHuz[4FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MUnJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6zN|Y6QSEQvF2= MUnTRW5ITVJ?
human MHH-PREB-1 cell NXW4Um81T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3rtWGlvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLWDSSWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwN{i4NVch|ryP M4W5enNCVkeHUh?=
human NCI-H510A cell M2TPWGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFfmSmZKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3IOVExSSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwMEO1N|Uh|ryP MnniV2FPT0WU
human NCI-H720 cell NFLEUXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M{XLWGlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV5Mk[4JO69VQ>? NEnLS49USU6JRWK=
human MRK-nu-1 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MVHJcohq[mm2aX;uJI9nKGi3bXHuJG1TUy2wdT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{44PTF5MTFOwG0> NWPtbZptW0GQR1XS
human LB2518-MEL cell NXPPV3BZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUXJcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njl5M{K2JO69VQ>? MnfzV2FPT0WU
human BE-13 cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mo[1TY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNlY5PCEQvF2= MWPTRW5ITVJ?
human A3-KAW cell MUHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVf2[JJbUW6qaXLpeIlwdiCxZjDoeY1idiCDMz3LRXch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05NjR|Mki5JO69VQ>? NI\vO|lUSU6JRWK=
human ST486 cell NXixVVBET3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NI\qU|VKdmirYnn0bY9vKG:oIHj1cYFvKFOWNEi2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE42OzZ6IN88US=> NFHxZXFUSU6JRWK=
human ES8 cell NF7zXZdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXPCUHJzUW6qaXLpeIlwdiCxZjDoeY1idiCHU{igZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24MlY1OzN7IN88US=> NELDVGlUSU6JRWK=
human HT cell M3fTVWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2LqdGlvcGmkaYTpc44hd2ZiaIXtZY4hUFRiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD16Lkm0NVg2KM7:TR?= NIfuVFdUSU6JRWK=
human HAL-01 cell MoHtS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NFHPTZVKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOzF3MEWg{txO MlTaV2FPT0WU
human EB-3 cell NGfFTopIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MnKwTY5pcWKrdHnvckBw\iCqdX3hckBGSi1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT62NlU4OiEQvF2= MX\TRW5ITVJ?
human EW-1 cell M2r5bmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NEfjWYtKdmirYnn0bY9vKG:oIHj1cYFvKEWZLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlcyOjRizszN M1jxSnNCVkeHUh?=
human BL-41 cell NXTKPXdST3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoWzTY5pcWKrdHnvckBw\iCqdX3hckBDVC12MTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuO|gxPDlizszN MYHTRW5ITVJ?
Ramos-2G6-4C10 cell NH7DVXNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWfk[mQyUW6qaXLpeIlwdiCxZjDoeY1idiCUYX3vd{0zTzZvNFOxNEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvQTB|MUWg{txO NVjDfW1EW0GQR1XS
human DOHH-2 cell NYTU[5hJT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NXPqSFh{UW6qaXLpeIlwdiCxZjDoeY1idiCGT1jIMVIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC5{Mk[yJO69VQ>? M2P2TnNCVkeHUh?=
MONO-MAC-6 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoLkTY5pcWKrdHnvckBw\iCqdX3hckBOV06RLV3BR{03KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTBwNUS4N{DPxE1? NEm5U5VUSU6JRWK=
human NKM-1 cell M3SwSmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M13nOmlvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43OTl4IN88US=> NV3FNnRIW0GQR1XS
human HEL cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXXJcohq[mm2aX;uJI9nKGi3bXHuJGhGVCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLk[yOVIh|ryP NGm0NVhUSU6JRWK=
human 8-MG-BA cell MXLHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MlnkTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQTl7OTFOwG0> M4TXeHNCVkeHUh?=
human K-562 cell NFXiTHpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= Mm\HTY5pcWKrdHnvckBw\iCqdX3hckBMNTV4MjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlAyQTFizszN M{K4N3NCVkeHUh?=
human LXF-289 cell NWX4bGVqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlO2TY5pcWKrdHnvckBw\iCqdX3hckBNYEZvMki5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOTV2NzFOwG0> NE[3c5JUSU6JRWK=
human HC-1 cell MULHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NYLjbHNtUW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOTV2NzFOwG0> MnzQV2FPT0WU
human MC116 cell NGflU4VIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH7pcIZKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOjB5MzFOwG0> NF3qeJVUSU6JRWK=
human TE-12 cell MmHES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NI\lUXFKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOzN3NzFOwG0> NF3TcY5USU6JRWK=
human BV-173 cell MnvLS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M37EXGlvcGmkaYTpc44hd2ZiaIXtZY4hSlZvMUezJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPTB{MTFOwG0> MX\TRW5ITVJ?
human NCCIT cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmfqTY5pcWKrdHnvckBw\iCqdX3hckBPS0OLVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlYxOzlizszN MmfnV2FPT0WU
human CESS cell NF\3PWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWPx[VRsUW6qaXLpeIlwdiCxZjDoeY1idiCFRWPTJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjZ4MjFOwG0> NFPNVZpUSU6JRWK=
human HUTU-80 cell NGPKRXpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXvKWVdyUW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNkewOEDPxE1? MVLTRW5ITVJ?
human IST-SL2 cell NUDsOpRmT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NIL4RYhKdmirYnn0bY9vKG:oIHj1cYFvKEmVVD3TUFIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS55N{C0JO69VQ>? M3fVW3NCVkeHUh?=
human ATN-1 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mk\GTY5pcWKrdHnvckBw\iCqdX3hckBCXE5vMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlAzOjZizszN MUXTRW5ITVJ?
human HCC1599 cell NInYTVlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlXwTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzNUm5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvOTB7NDFOwG0> M4POUXNCVkeHUh?=
human NTERA-S-cl-D1 cell Mn7WS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MmPnTY5pcWKrdHnvckBw\iCqdX3hckBPXEWUQT3TMYNtNURzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuPFg5QCEQvF2= MWXTRW5ITVJ?
human EVSA-T cell MXHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXvJcohq[mm2aX;uJI9nKGi3bXHuJGVXW0FvVDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGyMlkzODRizszN MnrhV2FPT0WU
human NALM-6 cell MmPHS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3HxTmlvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NVMvODl{OTFOwG0> MUDTRW5ITVJ?
human KMOE-2 cell NYDsVlJzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NH;UUG9KdmirYnn0bY9vKG:oIHj1cYFvKEuPT1WtNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjFyOUKg{txO M1vNSXNCVkeHUh?=
human HL-60 cell NFnicmJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1TTWWlvcGmkaYTpc44hd2ZiaIXtZY4hUExvNkCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4{OzB6IN88US=> M13LZ3NCVkeHUh?=
human D-542MG cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFf4OnBKdmirYnn0bY9vKG:oIHj1cYFvKERvNUSyUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy52M{C2JO69VQ>? MVnTRW5ITVJ?
human L-363 cell NV\mNXltT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MUPJcohq[mm2aX;uJI9nKGi3bXHuJGwuOzZ|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuOVU5OyEQvF2= NULRbZNJW0GQR1XS
human CMK cell MXvHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MWPJcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF|Lke0N|Yh|ryP MVzTRW5ITVJ?
human IMR-5 cell NVzVOFdwT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M{PoPGlvcGmkaYTpc44hd2ZiaIXtZY4hUU2ULUWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{44QDR7IN88US=> M3;UOnNCVkeHUh?=
human A101D cell NXzyUmd4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHHGfnVKdmirYnn0bY9vKG:oIHj1cYFvKEFzMEHEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQDJyNzFOwG0> M4\rfXNCVkeHUh?=
human MOLT-16 cell NIi0XWlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHriVG1KdmirYnn0bY9vKG:oIHj1cYFvKE2RTGStNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOy57Nk[1JO69VQ>? NGPwOlhUSU6JRWK=
human LU-139 cell NWnrToJWT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWHkc49DUW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC5yNES0JO69VQ>? NHnWNXdUSU6JRWK=
human OVCAR-4 cell MmjmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjwW4duUW6qaXLpeIlwdiCxZjDoeY1idiCRVlPBVk01KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTRwN{[wOEDPxE1? M1X2bnNCVkeHUh?=
human BC-3 cell Mlq3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX7JfooxUW6qaXLpeIlwdiCxZjDoeY1idiCEQz2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvPzl6MjFOwG0> NFO4NIRUSU6JRWK=
PC12 cells NVnsWHROTnWwY4Tpc44h[XO|YYm= M1\LN2N6fG:ycn;0[YN1cX[nIHHjeIl3cXS7IH;uJJJifCC2dX7pZ4FugWOrbjD0doVifGWmIILheEBxcGWxY3jyc41w[3m2b33hJINmdGxibHnu[UBRSzF{IH\yc40h[XCxcITvd4l{KGmwZIXj[YQh[nliRX7kc5Bt[XOvaXOgdoV1cWO3bIXtJJN1emW|czygSWM2OD1zNTFOwG0> NInQ[FgyPjByMkK4PC=>
human D-336MG cell Ml\PS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGDTbIhKdmirYnn0bY9vKG:oIHj1cYFvKERvM{O2UWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPS5zMUO0JO69VQ>? NVLtcHUzW0GQR1XS
human BC-1 cell NVXMdHhkT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT6xPVgh|ryP MkHVV2FPT0WU
human KE-37 cell MV\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M1r0XWlvcGmkaYTpc44hd2ZiaIXtZY4hU0VvM{egZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4zQDJ2IN88US=> MWTTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID