Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
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  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell M{jDRmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MVTJcohq[mm2aX;uJI9nKGi3bXHuJGxRNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|LkO3NVEzKM7:TR?= M2\ONHNCVkeHUh?=
human 697 cell NF;UPIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NHfLXo5KdmirYnn0bY9vKG:oIHj1cYFvKDZ7NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUOuPVg4QDhizszN M4fGfnNCVkeHUh?=
human ALL-PO cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXTJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNFg3PTVizszN M2fsfXNCVkeHUh?=
human ML-2 cell MWHHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4HNUWlvcGmkaYTpc44hd2ZiaIXtZY4hVUxvMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuOlE5OzNizszN NWrJfY05W0GQR1XS
human LB2241-RCC cell MoXBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NELLe2RKdmirYnn0bY9vKG:oIHj1cYFvKEyEMkK0NU1TS0NiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD12Lkm4OVczKM7:TR?= NELNZ|BUSU6JRWK=
human Becker cell NYnYPGdZT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NILmXVFKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzl2MEGg{txO MVXTRW5ITVJ?
human NEC8 cell MlSyS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MlK4TY5pcWKrdHnvckBw\iCqdX3hckBPTUN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6wOVM{OSEQvF2= MUPTRW5ITVJ?
human Daudi cell Mn7SS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGRifWSrIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;Nj6zN|Y6QSEQvF2= MXLTRW5ITVJ?
human MHH-PREB-1 cell NHHVNnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1LQbmlvcGmkaYTpc44hd2ZiaIXtZY4hVUiKLWDSSWIuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZwN{i4NVch|ryP MWfTRW5ITVJ?
human NCI-H510A cell M1vsPWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M3\aSWlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NVBCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py5yM{WzOUDPxE1? M2fCTnNCVkeHUh?=
human NCI-H720 cell M{O1RWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXzJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KN{KwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{42PzJ4ODFOwG0> NGTvb5VUSU6JRWK=
human MRK-nu-1 cell NYrhSWVyT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUnlW4VRUW6qaXLpeIlwdiCxZjDoeY1idiCPUlutcpUuOSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTdwN{WxO|Eh|ryP NHjIW|VUSU6JRWK=
human LB2518-MEL cell NG\BcYhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MU\Jcohq[mm2aX;uJI9nKGi3bXHuJGxDOjVzOD3NSWwh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04Njl5M{K2JO69VQ>? MYrTRW5ITVJ?
human BE-13 cell NX3zZoxMT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NELiOIxKdmirYnn0bY9vKG:oIHj1cYFvKEKHLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE4zPjh2IN88US=> Mm[wV2FPT0WU
human A3-KAW cell MU\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHXuOW1KdmirYnn0bY9vKG:oIHj1cYFvKEF|LVvBW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPDN{OEmg{txO MnLuV2FPT0WU
human ST486 cell Mn3ZS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NInCS4FKdmirYnn0bY9vKG:oIHj1cYFvKFOWNEi2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE42OzZ6IN88US=> MkKwV2FPT0WU
human ES8 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHtbIxKdmirYnn0bY9vKG:oIHj1cYFvKEWVODDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuOlQ{OzlizszN Moj2V2FPT0WU
human HT cell MluwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NImyVFhKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD65OFE5PSEQvF2= MYPTRW5ITVJ?
human HAL-01 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF;3OWJKdmirYnn0bY9vKG:oIHj1cYFvKEiDTD2wNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVkvOzF3MEWg{txO MnT6V2FPT0WU
human EB-3 cell MnfBS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3n4bGlvcGmkaYTpc44hd2ZiaIXtZY4hTUJvMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUmuOlI2PzJizszN NVGwTnQ4W0GQR1XS
human EW-1 cell NFrkOGJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MYfJcohq[mm2aX;uJI9nKGi3bXHuJGVYNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17LkexNlQh|ryP M3TpVXNCVkeHUh?=
human BL-41 cell M2q3Tmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nWOGlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvNEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25Mlc5ODR7IN88US=> M1r6fnNCVkeHUh?=
Ramos-2G6-4C10 cell MWrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3qwemlvcGmkaYTpc44hd2ZiaIXtZY4hWmGvb4OtNmc3NTSFMUCgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25MlkxOzF3IN88US=> MWXTRW5ITVJ?
human DOHH-2 cell NULhfnRbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmTkTY5pcWKrdHnvckBw\iCqdX3hckBFV0iKLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE4zOjZ{IN88US=> MX7TRW5ITVJ?
MONO-MAC-6 cell MmTPS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVSy[GpVUW6qaXLpeIlwdiCxZjDoeY1idiCPT17PMW1CSy14IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOVQ5OyEQvF2= NWXpdHVwW0GQR1XS
human NKM-1 cell MmH2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5MVS1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUCuOlE6PiEQvF2= MoPpV2FPT0WU
human HEL cell NInlOIVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\EO4ZKdmirYnn0bY9vKG:oIHj1cYFvKEiHTDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlYzPTJizszN MXPTRW5ITVJ?
human 8-MG-BA cell NVX1PXNpT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlLOTY5pcWKrdHnvckBw\iCqdX3hckA5NU2JLVLBJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVAvQTl7OTFOwG0> M4e5TXNCVkeHUh?=
human K-562 cell MoTxS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NXr3VnFuUW6qaXLpeIlwdiCxZjDoeY1idiCNLUW2NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjBzOUGg{txO NGfK[4FUSU6JRWK=
human LXF-289 cell M{nud2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M{jLVGlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjF3NEeg{txO NU\rfIZIW0GQR1XS
human HC-1 cell NXvm[5hIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHroToFKdmirYnn0bY9vKG:oIHj1cYFvKEiFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4yPTR5IN88US=> NGPWeFVUSU6JRWK=
human MC116 cell NGDUbHlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlvOTY5pcWKrdHnvckBw\iCqdX3hckBOSzFzNjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlIxPzNizszN NEDXW2ZUSU6JRWK=
human TE-12 cell Mn3NS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MonFTY5pcWKrdHnvckBw\iCqdX3hckBVTS1zMjDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlM{PTdizszN NXjIS2tkW0GQR1XS
human BV-173 cell NX7SfHNIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3XTY5pcWKrdHnvckBw\iCqdX3hckBDXi1zN{OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU42ODJzIN88US=> MWDTRW5ITVJ?
human NCCIT cell M3;hbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NXj3SJhXUW6qaXLpeIlwdiCxZjDoeY1idiCQQ1PJWEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjZyM{mg{txO NEezXY5USU6JRWK=
human CESS cell MlnMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MkP6TY5pcWKrdHnvckBw\iCqdX3hckBETVOVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuOlY3OiEQvF2= NGW3SYNUSU6JRWK=
human HUTU-80 cell NVXmUlVIT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVGzcIpRUW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTFwNkewOEDPxE1? M2HlenNCVkeHUh?=
human IST-SL2 cell NFi5NnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MXXJcohq[mm2aX;uJI9nKGi3bXHuJGlUXC2VTEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU44PzB2IN88US=> MXPTRW5ITVJ?
human ATN-1 cell NFXLcG1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MWHJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuNFIzPiEQvF2= MonHV2FPT0WU
human HCC1599 cell NU\tSXZqT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NFfrcopKdmirYnn0bY9vKG:oIHj1cYFvKEiFQ{G1PVkh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi5zMEm0JO69VQ>? NH\EPWRUSU6JRWK=
human NTERA-S-cl-D1 cell NEnUcFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVfRcJpEUW6qaXLpeIlwdiCxZjDoeY1idiCQVFXSRU1UNWOuLVSxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvQDh6ODFOwG0> NE\1[FFUSU6JRWK=
human EVSA-T cell Mn3GS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NV7DdVZ[UW6qaXLpeIlwdiCxZjDoeY1idiCHVmPBMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi57MkC0JO69VQ>? MX3TRW5ITVJ?
human NALM-6 cell MXzHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDnTY5pcWKrdHnvckBw\iCqdX3hckBPSUyPLU[gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfU4hUUN3ME2xN{4xQTJ7IN88US=> NXLFTZF4W0GQR1XS
human KMOE-2 cell MUnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2DsZ2lvcGmkaYTpc44hd2ZiaIXtZY4hU02RRT2yJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvOTB7MjFOwG0> Mnj5V2FPT0WU
human HL-60 cell NWjwfotRT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MlfWTY5pcWKrdHnvckBw\iCqdX3hckBJVC14MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlM{ODhizszN M1v5RnNCVkeHUh?=
human D-542MG cell NX[0fYhDT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= Ml3tTY5pcWKrdHnvckBw\iCqdX3hckBFNTV2Ml3HJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPDNyNjFOwG0> M1[xSnNCVkeHUh?=
human L-363 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NXTOTnJmUW6qaXLpeIlwdiCxZjDoeY1idiCOLUO2N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{NjV3OEOg{txO NHj3[nNUSU6JRWK=
human CMK cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MkfPTY5pcWKrdHnvckBw\iCqdX3hckBEVUtiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zMz63OFM3KM7:TR?= NVzBTnA1W0GQR1XS
human IMR-5 cell NG\UVodIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGTTOXRKdmirYnn0bY9vKG:oIHj1cYFvKEmPUj21JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPzh2OTFOwG0> NE[3XHpUSU6JRWK=
human A101D cell NGCyTpVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NFrDWmRKdmirYnn0bY9vKG:oIHj1cYFvKEFzMEHEJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvQDJyNzFOwG0> M33CZnNCVkeHUh?=
human MOLT-16 cell MkLMS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVW3O4tEUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwOU[2OUDPxE1? M1HiNnNCVkeHUh?=
human LU-139 cell MniwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NHrzU3NKdmirYnn0bY9vKG:oIHj1cYFvKEyXLUGzPUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1NjB2NESg{txO NVT0NI1DW0GQR1XS
human OVCAR-4 cell MkTXS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3rJUWlvcGmkaYTpc44hd2ZiaIXtZY4hV1[FQWKtOEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE1Njd4MESg{txO NF3vPWpUSU6JRWK=
human BC-3 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHjJOWhKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOE44QTh{IN88US=> NF3zemtUSU6JRWK=
PC12 cells MYnGeY5kfGmxbjDhd5NigQ>? NWPzTlB1S3m2b4Dyc5Rm[3SrdnWgZYN1cX[rdImgc44hemG2IIT1colk[W27Y3nuJJRz\WG2ZXSgdoF1KHCqZX;jbJJwdW:leYTvcYEh[2WubDDsbY5mKFCFMUKg[pJwdSCjcH;weI9{cXNiaX7keYNm\CCkeTDFcoRweGyjc33pZ{Bz\XSrY4XseY0he3S{ZYPzMEBGSzVyPUG1JO69VQ>? MWixOlAxOjJ6OB?=
human D-336MG cell NYjpdFhiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M321fmlvcGmkaYTpc44hd2ZiaIXtZY4hTC1|M{\NS{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjFzM{Sg{txO NGTRRnNUSU6JRWK=
human BC-1 cell NF\rTnNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIjpd|lKdmirYnn0bY9vKG:oIHj1cYFvKEKFLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yQThizszN MXfTRW5ITVJ?
human KE-37 cell NYLFW3l4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NY[zOFdpUW6qaXLpeIlwdiCxZjDoeY1idiCNRT2zO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE2NjJ6MkSg{txO NYX6cIFmW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID