Salubrinal

Catalog No.S2923

Salubrinal Chemical Structure

Molecular Weight(MW): 479.81

Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.

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In DMSO USD 280 In stock
USD 147 In stock
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  • AngII (30 minutes)-induced Akt activation was attenuated by the ER stress inhibitors 4-PBA (5 mM, 2 hours), TUDCA (300 µg/ml, 1 hour), and salubrinal (30 µM, 1 hour) (n=5; *P<0.01 versus con, #P<0.05 versus Ang)

    J Am Soc Nephrol, 2015, 26(8):1839-54. . Salubrinal purchased from Selleck.

    PC-3 and HCT-116 p53+/+ cells were treated with 3-AWA and/or salubrinal for the indicated time point. The protein-specific antibodies were used to analyze the expression of the given proteins through immunoblotting.

    Oncogenesis, 2017, 6(5):e341. Salubrinal purchased from Selleck.

  • HEK293 cells were transfected with or without Flag-VP1 for 24 h, then treated with d Salubrinal (Sal, 75 μM) for 8 h followed by immunoblot detection. All data in this figure represent the mean ± SEM of three independent experiments. *p<0.05; ***p<0.01.

    Neurotox Res, 2017, 31(2):204-217. Salubrinal purchased from Selleck.

Purity & Quality Control

Choose Selective PERK Inhibitors

Biological Activity

Description Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Targets
eIF2α [1]
(Cell-free assay)
In vitro

Salubrinal is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Salubrinal inhibited ER stress-mediated apoptosis induced by the protein glycosylation inhibitor tunicamycin (Tm) in a dose-dependent manner, with a median effective concentration (EC50) ∼ 15 μM. Salubrinal also suppressed Tm-induced DNA fragmentation the processing of caspase-7, a caspase activated by ER stress. However, Salubrinal is not a general apoptosis inhibitor. Salubrinal induced rapid and robust eIF2α phosphorylation and its downstream effects in PC12 cells, including down-regulation of cyclin D1 and up-regulation of GADD34 and CHOP, two proteins whose expression is induced by eIF2α phosphorylation. Salubrinal inhibits eIF2α dephosphorylation by inhibiting the PP1/GADD34 complex. Salubrinal inhibits HSV replication with IC50 of ~ 3μM by inhibiting eIF2α dephosphorylation. [1] Salubrinal increased non-rapid eye movement (NREM) sleep. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human LP-1 cell MXnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NVuzOGlSUW6qaXLpeIlwdiCxZjDoeY1idiCOUD2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9N{4{PzFzMjFOwG0> M4DreXNCVkeHUh?=
human 697 cell MY\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MmDoTY5pcWKrdHnvckBw\iCqdX3hckA3QTdiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Lkm4O|g5KM7:TR?= NE\ZRnpUSU6JRWK=
human ALL-PO cell Mmf6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVrJcohq[mm2aX;uJI9nKGi3bXHuJGFNVC2STzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUSuNFg3PTVizszN NFXSOHlUSU6JRWK=
human ML-2 cell M3:4U2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFfpc49KdmirYnn0bY9vKG:oIHj1cYFvKE2OLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20MlYyQDN|IN88US=> MWLTRW5ITVJ?
human LB2241-RCC cell NUSxelJiT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2XkNWlvcGmkaYTpc44hd2ZiaIXtZY4hVEJ{MkSxMXJESyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTRwOUi1O|Ih|ryP M2rkN3NCVkeHUh?=
human Becker cell M13oXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIfBZ3lKdmirYnn0bY9vKG:oIHj1cYFvKEKnY3vldkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVUvPzl2MEGg{txO NF3rZXRUSU6JRWK=
human NEC8 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MYTJcohq[mm2aX;uJI9nKGi3bXHuJG5GSzhiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD14LkC1N|MyKM7:TR?= MnyxV2FPT0WU
human Daudi cell M3Lm[mdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 Mm\yTY5pcWKrdHnvckBw\iCqdX3hckBF[XWmaTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPU[uN|M3QTlizszN Mn35V2FPT0WU
human MHH-PREB-1 cell NGTSWnpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVLJcohq[mm2aX;uJI9nKGi3bXHuJG1JUC2SUlXCMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF03Njd6OEG3JO69VQ>? MnrWV2FPT0WU
human NCI-H510A cell M4PiVmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1XCSmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi1NVBCKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py5yM{WzOUDPxE1? MVjTRW5ITVJ?
human NCI-H720 cell NWTjS2U1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3vEcmlvcGmkaYTpc44hd2ZiaIXtZY4hVkOLLVi3NlAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF04NjV5Mk[4JO69VQ>? NXnpUHhqW0GQR1XS
human MRK-nu-1 cell M4raOmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG1TUy2wdT2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O{44PTF5MTFOwG0> NUTJXmUxW0GQR1XS
human LB2518-MEL cell NULnSWQ2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmPJTY5pcWKrdHnvckBw\iCqdX3hckBNSjJ3MUitUWVNKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:Py57N{OyOkDPxE1? MVPTRW5ITVJ?
human BE-13 cell MUPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mo\pTY5pcWKrdHnvckBw\iCqdX3hckBDTS1zMzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUiuNlY5PCEQvF2= MWHTRW5ITVJ?
human A3-KAW cell NX[wdldPT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHP2OnhKdmirYnn0bY9vKG:oIHj1cYFvKEF|LVvBW{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgvPDN{OEmg{txO Mki3V2FPT0WU
human ST486 cell NFm3TFhIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIS3TZVKdmirYnn0bY9vKG:oIHj1cYFvKFOWNEi2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PE42OzZ6IN88US=> Ml\LV2FPT0WU
human ES8 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4W2VGlvcGmkaYTpc44hd2ZiaIXtZY4hTVN6IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD62OFM{QSEQvF2= NHLkU4lUSU6JRWK=
human HT cell MlraS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NGmzWFVKdmirYnn0bY9vKG:oIHj1cYFvKEiWIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OD65OFE5PSEQvF2= NWrVNZc4W0GQR1XS
human HAL-01 cell NGCxbZRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M1fySGlvcGmkaYTpc44hd2ZiaIXtZY4hUEGOLUCxJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU4{OTVyNTFOwG0> M{G4bHNCVkeHUh?=
human EB-3 cell NH\rTZFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX2y[Gk2UW6qaXLpeIlwdiCxZjDoeY1idiCHQj2zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PU43OjV5MjFOwG0> MmmwV2FPT0WU
human EW-1 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnnxTY5pcWKrdHnvckBw\iCqdX3hckBGXy1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT63NVI1KM7:TR?= NUTVU5V5W0GQR1XS
human BL-41 cell MmP4S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{\rTmlvcGmkaYTpc44hd2ZiaIXtZY4hSkxvNEGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME25Mlc5ODR7IN88US=> MVHTRW5ITVJ?
Ramos-2G6-4C10 cell NF\Odm1Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MVPJcohq[mm2aX;uJI9nKGi3bXHuJHJidW:|LULHOk01SzFyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OT65NFMyPSEQvF2= NVLCPVRsW0GQR1XS
human DOHH-2 cell MX;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHLs[2FKdmirYnn0bY9vKG:oIHj1cYFvKESRSFitNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVExNjJ{NkKg{txO MlXHV2FPT0WU
MONO-MAC-6 cell M2DBTWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4\IdGlvcGmkaYTpc44hd2ZiaIXtZY4hVU:QTz3NRWMuPiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTFyLkW0PFMh|ryP M{PnO3NCVkeHUh?=
human NKM-1 cell NXzseIZFT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M2HX[2lvcGmkaYTpc44hd2ZiaIXtZY4hVkuPLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNE43OTl4IN88US=> NIG3NZJUSU6JRWK=
human HEL cell M1jTUGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NHjGR|RKdmirYnn0bY9vKG:oIHj1cYFvKEiHTDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGwMlYzPTJizszN MWPTRW5ITVJ?
human 8-MG-BA cell M4T4NGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NGPFdHRKdmirYnn0bY9vKG:oIHj1cYFvKDhvTVetRmEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOC57OUm5JO69VQ>? NYXFc3ZqW0GQR1XS
human K-562 cell M37B[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MV;Jcohq[mm2aX;uJI9nKGi3bXHuJGsuPTZ{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuNFE6OSEQvF2= M2PROXNCVkeHUh?=
human LXF-289 cell MoCwS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MVXJcohq[mm2aX;uJI9nKGi3bXHuJGxZTi1{OEmgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNU4yPTR5IN88US=> MlX3V2FPT0WU
human HC-1 cell NGfyUWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NX:3d2I5UW6qaXLpeIlwdiCxZjDoeY1idiCKQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOTV2NzFOwG0> NVj2[|hbW0GQR1XS
human MC116 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFjQeVdKdmirYnn0bY9vKG:oIHj1cYFvKE2FMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOjB5MzFOwG0> M{LJWHNCVkeHUh?=
human TE-12 cell NFOzOI9Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIi2[4ZKdmirYnn0bY9vKG:oIHj1cYFvKFSHLUGyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvOzN3NzFOwG0> MXHTRW5ITVJ?
human BV-173 cell NHfLboFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NXS3XHhZUW6qaXLpeIlwdiCxZjDoeY1idiCEVj2xO|Mh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS53MEKxJO69VQ>? NIS5W3FUSU6JRWK=
human NCCIT cell NGHnSmRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NGLNZlBKdmirYnn0bY9vKG:oIHj1cYFvKE6FQ1nUJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVEvPjB|OTFOwG0> NHPHWG9USU6JRWK=
human CESS cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MorCTY5pcWKrdHnvckBw\iCqdX3hckBETVOVIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUGuOlY3OiEQvF2= NWexOmw1W0GQR1XS
human HUTU-80 cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHvzdpdKdmirYnn0bY9vKG:oIHj1cYFvKEiXVGWtPFAh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOS54N{C0JO69VQ>? NYjLenZPW0GQR1XS
human IST-SL2 cell MWnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{m5S2lvcGmkaYTpc44hd2ZiaIXtZY4hUVOWLWPMNkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVEyNjd5MESg{txO M3ixV3NCVkeHUh?=
human ATN-1 cell NYfBNZMxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYHJcohq[mm2aX;uJI9nKGi3bXHuJGFVVi1zIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUKuNFIzPiEQvF2= MYLTRW5ITVJ?
human HCC1599 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Mo\VTY5pcWKrdHnvckBw\iCqdX3hckBJS0NzNUm5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVIvOTB7NDFOwG0> NIewXIFUSU6JRWK=
human NTERA-S-cl-D1 cell Mn;RS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIr6VHdKdmirYnn0bY9vKG:oIHj1cYFvKE6WRWLBMXMu[2xvREGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xNk45QDh6IN88US=> MXLTRW5ITVJ?
human EVSA-T cell MnWzS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYP3c|IyUW6qaXLpeIlwdiCxZjDoeY1idiCHVmPBMXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yOi57MkC0JO69VQ>? NXzrUoJ{W0GQR1XS
human NALM-6 cell NILhT|BIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3HIU2lvcGmkaYTpc44hd2ZiaIXtZY4hVkGOTT22JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZkvKEmFNUC9NVMvODl{OTFOwG0> MV\TRW5ITVJ?
human KMOE-2 cell M{jLbGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MoTtTY5pcWKrdHnvckBw\iCqdX3hckBMVU:HLUKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xN{4yODl{IN88US=> NYD5PXpFW0GQR1XS
human HL-60 cell M4fOdmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUXJcohq[mm2aX;uJI9nKGi3bXHuJGhNNTZyIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUOuN|MxQCEQvF2= NUfYdYRDW0GQR1XS
human D-542MG cell NXH6dGJ1T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NUf5dVc4UW6qaXLpeIlwdiCxZjDoeY1idiCGLUW0Nm1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwNEOwOkDPxE1? MkixV2FPT0WU
human L-363 cell NYrpUVNzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGDYV41KdmirYnn0bY9vKG:oIHj1cYFvKExvM{[zJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVMvPTV6MzFOwG0> NUfCfItvW0GQR1XS
human CMK cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGNOUyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF|Lke0N|Yh|ryP Mk\aV2FPT0WU
human IMR-5 cell MWjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MorVTY5pcWKrdHnvckBw\iCqdX3hckBKVVJvNTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGzMlc5PDlizszN MnLwV2FPT0WU
human A101D cell NVfQfnhuT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWe2eI9RUW6qaXLpeIlwdiCxZjDoeY1idiCDMUCxSEBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVE{Njh{MEeg{txO MVvTRW5ITVJ?
human MOLT-16 cell MmrIS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NYT2fHRQUW6qaXLpeIlwdiCxZjDoeY1idiCPT1zUMVE3KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OTNwOU[2OUDPxE1? NXvtNZlIW0GQR1XS
human LU-139 cell NWn4SHl2T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NVzqR5F2UW6qaXLpeIlwdiCxZjDoeY1idiCOVT2xN|kh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC5yNES0JO69VQ>? M{\tT3NCVkeHUh?=
human OVCAR-4 cell M1:3cmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NFHkSlBKdmirYnn0bY9vKG:oIHj1cYFvKE:YQ1HSMVQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0yPC55NkC0JO69VQ>? NInXW3BUSU6JRWK=
human BC-3 cell MnrmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? Ml;zTY5pcWKrdHnvckBw\iCqdX3hckBDSy1|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUSuO|k5OiEQvF2= NYDWcW5oW0GQR1XS
PC12 cells NVn4OnlITnWwY4Tpc44h[XO|YYm= M1jEb2N6fG:ycn;0[YN1cX[nIHHjeIl3cXS7IH;uJJJifCC2dX7pZ4FugWOrbjD0doVifGWmIILheEBxcGWxY3jyc41w[3m2b33hJINmdGxibHnu[UBRSzF{IH\yc40h[XCxcITvd4l{KGmwZIXj[YQh[nliRX7kc5Bt[XOvaXOgdoV1cWO3bIXtJJN1emW|czygSWM2OD1zNTFOwG0> NYCyWY14OTZyMEKyPFg>
human D-336MG cell Mnn2S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MWTJcohq[mm2aX;uJI9nKGi3bXHuJGQuOzN4TVegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2xOU4yOTN2IN88US=> NGX0bnpUSU6JRWK=
human BC-1 cell M{jjRWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MXrJcohq[mm2aX;uJI9nKGi3bXHuJGJENTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1zNT6xPVgh|ryP MWrTRW5ITVJ?
human KE-37 cell MV3Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnX1TY5pcWKrdHnvckBw\iCqdX3hckBMTS1|NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG1MlI5OjRizszN MV\TRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo Salubrinal inhibits HSV replication in a mouse cornea infection model. Compared to vehicle control, topical Salubrinal treatment significantly reduced the viral titer recovered from eye swabs of infected animals. [1] I.C.V. administration of Salubrinal significantly modified the homeostatic sleep response. [3]

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: PC12
  • Concentrations: 0-100 μM
  • Incubation Time: 48 hours
  • Method: PC12 cells are plated in 384-well plates at 5000 cells per well in 40μL phenol red-freemedium containing 3μg/ml Tm to induce ER stress. 100 nL of the DiverSet E (5 mg/mlin DMSO) or National Cancer Institute’s (NCI) Structural Diversity set and Open Collections (10 mM in DMSO) (NCI) are added to the wells by robotic pin transfer. After 48 hours, cell viability is assessed using a luminescence-based ATP assay. DMSO- and zVAD.fmk-treated wells on each plate served as negative and positive controls for rescue from ER stress-induced ATP loss, respectively.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Eight-week-old male CD-1 outbred mice
  • Formulation: in DMEM
  • Dosages: 75μM
  • Administration: On cornea
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 95 mg/mL (197.99 mM)
Ethanol 2 mg/mL (4.16 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 479.81
Formula

C21H17Cl3N4OS

CAS No. 405060-95-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID