Sal003

Catalog No.S7437

Sal003 Chemical Structure

Molecular Weight(MW): 463.21

Purity & Quality Control

Choose Selective phosphatase Inhibitors

Biological Activity

Description Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
Targets
eIF-2α phosphatase [1]
In vitro

Sal003 increases eIF2α phosphorylation status by blocking eIF2a phosphatases in cells. [1] In mouse embryonic fibroblasts (MEFs), Sal003 causes dissociation of polysomes by increasing eIF2a phosphorylation. Sal003 impairs late-long-term potentiation (L-LTP) in an ATF4-dependent mode in hippocampal slices from WT mice. [2] In addition, eIF2α phosphorylation by Sal003 also enhances apoptotic signaling induced by subtilase cytotoxin (SubAB). [3]

In vivo Sal003 impairs spatial long-term memory formation in rats. [2]

Protocol

Animal Research:[2]
+ Expand
  • Animal Models: Rats (300–325g body weight).
  • Formulation: Dissolved in DMSO and further diluted in 0.9% NaCl to a final DMSO concentration of 0.1%.
  • Dosages: 2 μL of 20 μM
  • Administration: Intrahippocampal Injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL (200.77 mM)
Water slightly soluble or insoluble
Ethanol slightly soluble or insoluble
In vivo

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 463.21
Formula

C18H15Cl4N3OS

CAS No. 1164470-53-4
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID