Pheniramine Maleate

Catalog No.S4045

Pheniramine Maleate Chemical Structure

Molecular Weight(MW): 356.42

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.

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Biological Activity

Description Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.
In vitro

Pheniramine Maleate is a histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Pheniramine appears to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors. [1]

Protocol

Solubility (25°C)

In vitro DMSO 71 mg/mL (199.2 mM)
Water 71 mg/mL (199.2 mM)
Ethanol 71 mg/mL (199.2 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 356.42
Formula

C16H20N2.C4H4O4

CAS No. 132-20-7
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02730364 Withdrawn Infections, Respiratory Tract GlaxoSmithKline February 2017 Phase 3
NCT01533220 Unknown status Flu|Cold|Allergic Disorder of Respiratory System EMS June 2013 Phase 3
NCT01390961 Unknown status Allergic Conjunctivitis Hom, Milton M., OD, FAAO|Allergan August 2011 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Histamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID