Home Transmembrane Transporters Sodium Channel inhibitor Phenazopyridine HCl For research use only.

Phenazopyridine HCl

Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.

Phenazopyridine HCl Chemical Structure

Phenazopyridine HCl Chemical Structure

CAS: 136-40-3

Selleck's Phenazopyridine HCl has been cited by 1 publication

Purity & Quality Control

Batch: S423501 DMSO] 50 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.99%
99.99

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Signaling Pathway

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Biological Activity

Description Phenazopyridine HCl is a local analgesic that has been used in urinary tract disorders. It is an inhibitor of sodium channel protein type 1 subunit alpha.
In vitro
In vitro Phenazopyridine: (i) enhanced neuronal differentiation, (ii) increased cell survival, (iii) decreased the amount of non-neuronal and undifferentiated cells and (iv) synchronized the cellular differentiation state.
In Vivo
In vivo Phenazopyridine can directly inhibit the mechanosensitive Aδ-fibers in the normal rat bladder.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00743977 Unknown status
Human Volunteers
Universal Enterprises
 August 2008 Not Applicable

Chemical Information & Solubility

Molecular Weight 249.7 Formula

C11H11N5.HCl
CAS No. 136-40-3 SDF Download Phenazopyridine HCl SDF
Smiles C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 50 mg/mL ( (200.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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