Name: OG-L002
Brand: Selleck Chemicals
SKU: S7237
Availability: InStock
Rating: 5 (19 reviews)

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Batch: S723701 DMSO]45 mg/mL]false]Ethanol]19 mg/mL]false]Water]Insoluble]false Purity: 99.8%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.8

Related Targets	HDAC JAK BET Histone Methyltransferase PKC PARP HIF PRMT EZH2 AMPK
Other Histone Demethylase Inhibitors	GSK-J4 Hydrochloride SP2509 GSK-LSD1 2HCl Ladademstat (ORY-1001) Dihydrochloride JIB-04 CPI-455 HCl IOX1 GSK J1 ML324 CPI-455

Solubility

In vitro
Batch:

DMSO : 45 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 19 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG 300 2 5%Tween80 3 50% ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.000mg/ml (4.44mM)	Taking the 1 mL working solution as an example, add 50 μL of 20 mg/mL clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify; add 50 μL Tween-80 to the above system, mix evenly to clarify; Then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

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%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	225.29	Formula	C₁₅H₁₅NO	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1357302-64-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1C(C1N)C2=CC=C(C=C2)C3=CC(=CC=C3)O

Mechanism of Action

Features	This selective LSD1 inhibitor was discovered in 2013. Potential for use in viral diseases such as HSV and VZV.
Targets/IC₅₀/Ki	LSD1 (Cell-free assay) 20 nM
In vitro	TCN 201 partially inhibits the NMDA-induced intracellular Ca²⁺ response in a concentration-dependent manner with a pIC50 of 6.4. TCN 201 partially inhibits [³H]CGP 39653 specific binding showing a maximal radioligand displacement of 44%, respectively, and a pIC50 of 6.5. TCN 201 at a concentration of 10 μM does not protect against Tat-induced cell death, in contrast to ifenprodil and memantine. However, this same concentration of TCN 201 prevents Tat-induced synapse loss. TCN 201 inhibits synapse recovery after Tat-induced loss. TCN 201 demonstrates potent but GluN1 co-agonist concentration-dependent inhibition of GluN1/GluN2A NMDAR-mediated responses. TCN 201 causes substantially less inhibition of the TEVC current trace. TCN 201 is around 30-times more potent than TCN 213. In cortical neurones TCN 201 shows only modest antagonism of NMDAR-mediated currents recorded from young (DIV 9-10) neurones where GluN2B expression predominates. In older cultures (DIV 15-18) or in cultures where GluN2A subunits have been over-expressed TCN 201 gives a strong block that is negatively correlated with the degree of block produced by the GluN2B-selective antagonist, ifenprodil. TCN-201 binds to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 agonist binding domains.
Kinase Assay	LSD1 demethylation assay
Kinase Assay	The demethylase activity is measured by the release of H2O2 produced during the catalytic process, using the Amplex red peroxide/peroxidase-coupled assay kit. Each reaction is done in triplicate. The maximum LSD1 demethylase activity is obtained in the absence of inhibitor and corrected for background fluorescence. The K_i (IC50) of this compound is calculated as half-maximal activity.
In vivo	OG-L002 (6 to 40 mg/kg) represses HSV primary infection in a dose-dependent manner in a mouse model. Moreover, this compound also represses HSV reactivation from latency in a mouse ganglion explant model.
References	[1] https://pubmed.ncbi.nlm.nih.gov/23386436/

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OG-L002 Histone Demethylase inhibitor

Chemical Structure

Molecular Weight: 225.29