Home Transmembrane Transporters Sodium Channel inhibitor Levobupivacaine For research use only.

Levobupivacaine

Synonyms: Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine

Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. Levobupivacaine exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.

Levobupivacaine Chemical Structure

Levobupivacaine Chemical Structure

CAS: 27262-47-1

Purity & Quality Control

Batch: S518101 DMSO] 58 mg/mL] false] Ethanol] 58 mg/mL] false] Water] Insoluble] false Purity: 99.49%
99.49

Levobupivacaine Related Products

Signaling Pathway

Sodium Channel Signaling Pathways

Sodium Channel Signaling Pathway

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Biological Activity

Description Levobupivacaine (Chirocaine, (S)-(-)-Bupivacaine, L-(-)-Bupivacaine), the S (-)-enantiomer of bupivacaine, is a long-acting amide local anaesthetic used in analgesia and anaesthesia. Levobupivacaine exhibits effects on motor and sensory nerves by inhibiting the opening of voltage-gated sodium channels.
Targets
voltage-gated sodium channels [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04221568 Unknown status
Labor Pain
Assiut University
 March 1 2020 Phase 1
NCT03258697 Unknown status
Arthropathy
Chang Gung Memorial Hospital
 October 17 2017 Not Applicable

Chemical Information & Solubility

Molecular Weight 288.43 Formula

C18H28N2O
CAS No. 27262-47-1 SDF --
Smiles CCCCN1CCCCC1C(=O)NC2=C(C)C=CC=C2C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 58 mg/mL ( (201.08 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 58 mg/mL

Water : Insoluble


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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